Covid-19 severe outcomes genetic analysis for cytokine storm

COVID-19: Your Genetic Risk of Cytokine Storm

Find out if you're at genetic risk of one of the most feared outcomes of COVID-19 called 'cytokine storm.'

Cytokine storm is a potentially life-threatening overreaction of the immune system that can be triggered by COVID-19. When a cytokine storm occurs, it usually requires intensive care treatment and may lead to death.

New studies show that out-of-control immune response is a major cause of death among young, previously healthy patients infected with coronavirus.

Some individuals are predisposed to over-activation of the immune system by their own DNA. This app analyzes your DNA for a known genetic risk factor of cytokine storm.

This app generates a personalized report that includes:

  • a coronavirus genetic risk analysis
  • treatment options to consider in case of coronavirus infection
  • The Food and Supplement Guide For the Coronavirus by Chris Masterjohn, PhD 


Sample Report


This app reports individual genetic risk for severe outcomes of COVID-19 infection caused by high IL-6 levels promoting the cytokine storm condition. Additional coronavirus risk assessment is available with the Coronavirus DNA Health Assessment.

Up to 20 percent of symptomatic coronavirus infected individuals require hospitalization, with 5 percent overall in need for intensive care. While the elderly or individuals with underlying chronic health problems are at a higher risk of mortality, younger and generally healthy people have also succumbed to severe Covid-19 illness.

Studies emerging from China suggest that many patients who died of Covid-19 had an overly-active immune response that lead to their death1. This response, known as “cytokine storm”, is responsible for at least some of the serious and fatal cases among previously healthy, young patients2.

Cytokines are small proteins with a big role in activating elements of the immune system. IL-6 is a key pro-inflammatory cytokine crucial for normal function of our immune system. However, upregulation of IL-6 during certain viral infections may promote virus survival and/or exacerbation of clinical disease1. High levels of IL-6 produced in infected lungs lead to fatal organ dysfunction if left untreated 3.

Past experience showed that treating cytokine storms brought about by viral infections and autoimmune diseases have reduced death rates to as low as 27 percent of all expected deaths7. Blockade of the IL-6 cytokine has recently been reported to be in use in China with successful outcomes in individuals receiving this as part of their treatment4-6.

The genetic background of individuals may predispose them to higher IL-6 levels6-12,4. Polymorphisms in the IL-6 and IL-6 receptor genes, carried by 10-30% of the population, influence the magnitudes of common cold viruses5 and susceptibility to rapid decline in lung function6.

Testing genetic markers can significantly predict plasma IL-6 levels7–9. Get GeneInformed and discover your tendency for high IL-6 levels, risk for cytokine storms and proposed therapeutic avenue.

Complete Genome Analysis provides a comprehensive assessment of your DNA.

Once your DNA data is stored in your account, purchase this DNA report and then click the app's 'Start' button. You'll receive your report in about 30 minutes.

If your DNA data is not already stored in your account, you can either import your data from a DNA test you've already taken (such as from 23andMe or AncestryDNA) or you can order one of our DNA tests.

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Our Universal DNA Compatibility enables this app to work with DNA data from almost any genetic test including 23andMe, Ancestry, MyHeritage, FTDNA, and genome sequencing. Our clinical-grade 30x Whole Genome Sequencing test obtains data on 100% of your genome.

Use the Upload Center to upload and use your DNA test or genome sequencing data.

Powered by our Universal DNA Compatibility technology, this report is compatible with data from most genetic tests.


Test Compatibility   Format Compatibility   Variant Compatibility   Reference Genome Compatibility
Whole Genome Sequencing   FASTQ and FQ   SNP/SNV
(Single Nucleotide Variants)
  hg38 / GRCh38
Exome Sequencing   FASTA and FA       hg19 / GRCh37
Ultimate DNA Test   BAM       hg18 / GRCh36
23andMe   SAM       hg17 / GRCh35
AncestryDNA   CRAM        
MyHeritage   VCF        
Dante Labs   Genome VCF (gVCF and GVCF)        
Nebula Genomics   TXT        
Genes for Good   CSV        
Living DNA   TAB        
HomeDNA   gz and zip compressed files        
FTDNA   almost all other genetic data formats        
Silverberry Genomix            
Toolbox Genomics            
Full Genomes            
New Amsterdam Genomics            
almost all other genetic tests

The Covid-19 Severe Outcomes Genetic Analysis works with's genetic tests.

Compare to 23andMe, Ancestry and similar that test less than 0.1% of your genome.


    Ultimate DNA Test   Whole Genome Sequencing
Discounted Price   $69  $189   $399  $599
Amount of genome tested   1%   100%
Technology   Genotyping Microarray   Clinical-Grade 30x Genome Sequencing
Coronavirus Report Version   Plus Report   Comprehensive Report
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Wellness & Longevity Health Analysis

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Rare Disease Screen Analysis

Balakrishnan, V., Guo, D., Rao, M., Jaber, B., Tighiouart, H., Freeman, R., et al. (2004). Cytokine gene polymorphisms in hemodialysis patients: Association with comorbidity, functionality, and serum albumin. Kidney International, 65(4), 1449-1460.

Chen, X., Zhao, B., Qu, Y., Chen, Y., Xiong, J., Feng, Y., et al. (2020). Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients. medRxiv, 2020.02.29.20029520.

Cheung, B., Ong, K., Tso, A., Leung, R., Cherny, S., Sham, P., et al. (2011). Relationship of Plasma Interleukin-6 and Its Genetic Variants With Hypertension in Hong Kong Chinese. American Journal of Hypertension, 24(12), 1331-1337.

Chinese Clinical Trial Registery. (n.d.). Chinese Clinical Trial Register (ChiCTR) - The world health organization international clinical trials registered organization registered platform. Retrieved from

Doyle, W., Casselbrant, M., Li‐Korotky, H.‐S., Cullen Doyle, A., Lo, C.‐Y., Turner, R., et al. (2010). The Interleukin 6 −174 C/C Genotype Predicts Greater Rhinovirus Illness. The Journal of Infectious Diseases, 201(2), 199-206.

Hamzic-Mehmedbasic, A. (2016). Inflammatory Cytokines as Risk Factors for Mortality After Acute Cardiac Events. Medical archives (Sarajevo, Bosnia and Herzegovina), 70(4), 252-255.

He, J., Foreman, M., Shumansky, K., Zhang, X., Akhabir, L., Sin, D., et al. (2009). Associations of IL6 polymorphisms with lung function decline and COPD. Thorax, 64(8), 698-704.

Hu H, Ma F, Wei X, F. (n.d.). Coronavirus Fulminant Myocarditis Case Review - American College of Cardiology. Retrieved from

Jiang, C., Lam, T., Liu, B., Lin, J., Yue, X., Jin, Y., et al. (2010). Interleukin-6 receptor gene polymorphism modulates interleukin-6 levels and the metabolic syndrome: GBCS-CVD. Obesity, 18(10), 1969-1974.

Mehta, P., Mcauley, D., Brown, M., Sanchez, E., Tattersall, R., Manson, J., et al. (2020). Correspondence COVID-19 : consider cytokine storm syndromes and. The Lancet, 6736(20), 19-20.

Rafiq, S., Frayling, T., Murray, A., Hurst, A., Stevens, K., Weedon, M., et al. (2007). A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes and Immunity, 8(7), 552-559.

Ramos-Casals, M., Brito-Zerón, P., López-Guillermo, A., Khamashta, M., & Bosch, X. (2014). Adult haemophagocytic syndrome. The Lancet. 383, pp. 1503-1516. Lancet Publishing Group.

Regeneron, Sanofi Launch Clinical Trial of Kevzara as Coronavirus Treatment. Retrieved from

Richardson, P., Griffin, I., Tucker, C., Smith, D., Oechsle, O., Phelan, A., et al. (2020). Baricitinib as potential treatment for 2019-nCoV acute respiratory disease. The Lancet, 395(10223), e30-e31. Lancet Publishing Group.

Roch. Roche - Roche initiates Phase III clinical trial of Actemra/RoActemra in hospitalised patients with severe COVID-19 pneumonia. Retrieved from

Ruan, Q., Yang, K., Wang, W., Jiang, L., & Song, J. (2020). Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive care medicine, 1-3.

Schnabel, R., Lunetta, K., Larson, M., Dupuis, J., Lipinska, I., Rong, J., et al. (2009). The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations. Circulation: Cardiovascular Genetics, 2(3), 229-237.

Shah, T., Zabaneh, D., Gaunt, T., Swerdlow, D., Shah, S., Talmud, P., et al. (2013). Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers. Circulation: Cardiovascular Genetics, 6(2), 163-170.

Tanaka, T., Narazaki, M., & Kishimoto, T. (2016). Immunotherapeutic implications of IL-6 blockade for cytokine storm. Immunotherapy, 8(8), 959-970. Future Medicine Ltd.

Tyburski, J., Dente, C., Wilson, R., Steffes, C., Devlin, J., Carlin, A., et al. (2001). Differences in arterial and mixed venous IL-6 levels: The lungs as a source of cytokine storm in sepsis. Surgery, 130(4), 748-752.

Van Dongen, J., Jansen, R., Smit, D., Hottenga, J., Mbarek, H., Willemsen, G., et al. (2014). The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels. Behavior Genetics, 44(4), 368-382.

Vargas, V., Bonatto, S., Macagnan, F., Feoli, A., Alho, C., Santos, N., et al. (2013). Influence of the 48867A>C (Asp358Ala) IL6R polymorphism on response to a lifestyle modification intervention in individuals with metabolic syndrome. Genetics and Molecular Research, 12(3), 3983-3991.

Velazquez-Salinas, L., Verdugo-Rodriguez, A., Rodriguez, L., & Borca, M. (2019). The Role of Interleukin 6 During Viral Infections. Frontiers in Microbiology, 10(MAY), 1057.


Additional DNA Reports related to COVID-19

Covid-19 DNA Wellness Report         Covid-19 Health Assessment
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The genetic analysis and statements that appear in this app have not been evaluated by the United States Food and Drug Administration. The website and all software applications (Apps) that use's website, as well as's open Application Programming Interface (API), are not intended to diagnose, treat, cure, or prevent any disease.