Name: Medication Response DNA Report | Pharmacogenomics Analysis
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<h2><strong>Your DNA Report for Medication and Drug Reactions</strong></h2><h3>Advanced pharmacogenomics analysis</h3><p>The <strong>Medication &amp; Drug Response DNA Report</strong> includes information about your risk of <a href="https://sequencing.com/education-center/medication-side-effects"><span style="color:#5EB0F3">medication side effects</span></a> with common medications as well as your risk of addiction to certain medications and illicit drugs.</p><p>The report includes:</p><ul><li>Response to medications</li><li>Risk of harmful side effects</li><li>Risk of addiction <ul><li>Alcohol</li><li>Nicotine</li><li>Marijuana / Cannabis</li><li>Cocaine</li><li>Opiates</li></ul></li>
</ul><h3>Categories of medications included in the report</h3><ul><li>Anticoagulants</li><li>Antidepressants</li><li>Asthma Treatment</li><li>Cardiovascular Disease Treatment</li><li>Neuropathic Pain Treatment</li><li>Type-2 Diabetes Treatment</li><li>Medications that have an Addiction Risk</li><li>Illicit Drugs</li>
</ul><p>The complete list of medications and drugs is included in the 'List of Medications' tab.</p><p> </p><h2>Learn More About Medication Reactions</h2><p><img  src="https://sequencing.com/sites/default/files/dna_icon.png" style="height:150px; width:200px" /></p><p>Sequencing's Education Center includes several insightful articles about medication reactions. For example, you can learn about the <a href="https://sequencing.com/education-center/medication-side-effects/effects-medicine-body"><span style="color:#5EB0F3">effect of medicine on the body</span></a> as well as <a href="https://sequencing.com/education-center/medication-side-effects/how-reduce-side-effects-medicine"><span style="color:#5EB0F3">how to reduce the side effects of medicine</span></a>. Additional articles are added every week!</p><h2><a id="sample-report" name="sample-report"></a>Sample DNA Report</h2><p><iframe frameborder="0" scrolling="no" src="https://docs.google.com/gview?url=https://sequencing.com/sites/default/files/medication-and-drug-response-sample-dna-report.pdf&embedded=true" ></iframe></p>


<h2>Learn how your DNA impacts your response to medications and drugs.</h2><p><img  style="height: 200px; width: 300px;" src="https://sequencing.com/sites/default/files/wysiwyg/14/medication-pharmacogenomics-dna-report.jpg" /></p><h3><strong>Metabolism of some medicines (Anti-ulcer, Anti-platelet, Antidepressant)</strong></h3><ul><li>Common drugs such as Plavix, Omeprazole, Esomeprazole and more</li>
</ul><h3><strong>Risk of addiction</strong></h3><ul><li>Alcohol</li><li>Cannabis</li><li>Cocaine</li><li>Opiates including Heroin</li><li>Nicotine</li>
</ul><h3><strong>Medications used to treat infections</strong></h3><ul><li>Abacavir Hypersensitivity (HIV treatment)</li><li>Hepatitis C treatment response</li>
</ul><h3>Asthma treatment</h3><ul><li>Inhaled Glucocorticoids response</li><li>Salbutamol (Ventolin) response</li>
</ul><h3><strong>Diabetes medications</strong></h3><ul><li>Metformin Response (Type-2 Diabetes treatment)</li><li>Carbamazepine (Tegretol) Reaction (Neuropathic pain, epilepsy treatment) </li>
</ul><h3><strong>Heart medications</strong></h3><ul><li>Statin Response</li><li>Warfarin (Coumadin) Dosing (Anticoagulant)</li>
</ul><h3><strong>Medication to treat diseases common and rare diseases</strong></h3><ul><li>NSAID Response (Inflammation, fever, pain treatment)</li><li>Aromatase Inhibitor Side-Effects (Breast cancer treatment)</li><li>Carbamazepine (Tegretol) Reaction (Neuropathic pain, epilepsy treatment)</li><li>Citalopram (Celexa) Response (Antidepressant)</li><li>Cyclophosphamide Reaction (Chemotherapy)</li><li>Sorafenib Response (Liver cancer treatment)</li>
</ul>


<p>The following information is from the <a href="http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/009218s107lbl.pdf">FDA's labeling information for Warfarin</a> (Coumadin®).</p><h3>Warfarin Dosing Recommendations <em>with</em> Consideration of Genetic Data</h3><p>Table 1 below displays three ranges of expected maintenance COUMADIN doses observed in subgroups of patients having different combinations of CYP2C9 and VKORC1 gene variants [see <a href="https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/009218s107lbl.pdf" >Pharmacogenomics section 12.5</a>].</p><p>If the patient’s CYP2C9 and/or VKORC1 genotype are known, consider these ranges in choosing the initial dose. Patients with CYP2C9 *1/*3, *2/*2, *2/*3, and *3/*3 may require more prolonged time (&gt;2 to 4 weeks) to achieve maximum INR effect for a given dosage regimen than patients without these CYP variants.</p><p><strong>Table 1: Three Ranges of Expected Maintenance COUMADIN Daily Doses Based on CYP2C9 and VKORC1 Genotypes †</strong></p><table cellspacing="0" style="border-collapse:collapse;margin-left:5.63698pt"><tbody><tr style="height:15pt"><td rowspan="2" style="width: 74pt; border-style: solid; border-width: 1pt; text-align: center;"><p style="padding-top: 1pt; padding-left: 16pt; text-indent: 0pt;"><strong>VKORC1</strong></p></td><td colspan="6" style="width:405pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 183pt;padding-right: 182pt;text-indent: 0pt;text-align: center;"><strong>CYP2C9</strong></p></td></tr><tr style="height:15pt"><td style="width:75pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 22pt;padding-right: 21pt;text-indent: 0pt;text-align: center;">*1/*1</p></td><td style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 13pt;padding-right: 13pt;text-indent: 0pt;text-align: center;">*1/*2</p></td><td style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 21pt;text-indent: 0pt;text-align: left;">*1/*3</p></td><td style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 21pt;text-indent: 0pt;text-align: left;">*2/*2</p></td><td style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 21pt;text-indent: 0pt;text-align: left;">*2/*3</p></td><td style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 13pt;padding-right: 13pt;text-indent: 0pt;text-align: center;">*3/*3</p></td></tr><tr style="height:15pt"><td style="width:74pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 28pt;padding-right: 27pt;text-indent: 0pt;text-align: center;">GG</p></td><td bgcolor="#D1D1D1" style="width:75pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 22pt;padding-right: 21pt;text-indent: 0pt;text-align: center;">5-7 mg</p></td><td bgcolor="#D1D1D1" style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 13pt;padding-right: 13pt;text-indent: 0pt;text-align: center;">5-7 mg</p></td><td style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 18pt;text-indent: 0pt;text-align: left;">3-4 mg</p></td><td style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-right: 17pt;text-indent: 0pt;text-align: right;">3-4 mg</p></td><td style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-right: 17pt;text-indent: 0pt;text-align: right;">3-4 mg</p></td><td bgcolor="#B1B1B1" style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 13pt;padding-right: 13pt;text-indent: 0pt;text-align: center;">0.5-2 mg</p></td></tr><tr style="height:15pt"><td style="width:74pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 28pt;padding-right: 28pt;text-indent: 0pt;text-align: center;">AG</p></td><td bgcolor="#D1D1D1" style="width:75pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 22pt;padding-right: 21pt;text-indent: 0pt;text-align: center;">5-7 mg</p></td><td style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 13pt;padding-right: 13pt;text-indent: 0pt;text-align: center;">3-4 mg</p></td><td style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 18pt;text-indent: 0pt;text-align: left;">3-4 mg</p></td><td style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-right: 17pt;text-indent: 0pt;text-align: right;">3-4 mg</p></td><td bgcolor="#B1B1B1" style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-right: 13pt;text-indent: 0pt;text-align: right;">0.5-2 mg</p></td><td bgcolor="#B1B1B1" style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 13pt;padding-right: 13pt;text-indent: 0pt;text-align: center;">0.5-2 mg</p></td></tr><tr style="height:15pt"><td style="width:74pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 28pt;padding-right: 27pt;text-indent: 0pt;text-align: center;">AA</p></td><td style="width:75pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 22pt;padding-right: 21pt;text-indent: 0pt;text-align: center;">3-4 mg</p></td><td style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 13pt;padding-right: 13pt;text-indent: 0pt;text-align: center;">3-4 mg</p></td><td bgcolor="#B1B1B1" style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 15pt;text-indent: 0pt;text-align: left;">0.5-2 mg</p></td><td bgcolor="#B1B1B1" style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-right: 13pt;text-indent: 0pt;text-align: right;">0.5-2 mg</p></td><td bgcolor="#B1B1B1" style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-right: 13pt;text-indent: 0pt;text-align: right;">0.5-2 mg</p></td><td bgcolor="#B1B1B1" style="width:66pt;border-top-style:solid;border-top-width:1pt;border-left-style:solid;border-left-width:1pt;border-bottom-style:solid;border-bottom-width:1pt;border-right-style:solid;border-right-width:1pt"><p style="padding-top: 1pt;padding-left: 13pt;padding-right: 13pt;text-indent: 0pt;text-align: center;">0.5-2 mg</p></td></tr></tbody>
</table><p>† Ranges are derived from multiple published clinical studies. VKORC1 - 1639G&gt;A (rs9923231) variant is used in this table. Other co-inherited VKORC1 variants may also be important determinants of warfarin dose.</p><h3>Warfarin Dosing Recommendations <em>without</em> Consideration of Genetic Data</h3><p style="font-size: medium;">If the patient’s CYP2C9 and VKORC1 genotypes are not known, the initial dose of COUMADIN is usually 2 to 5 mg once daily.</p><p style="font-size: medium;">Determine each patient’s dosing needs by close monitoring of the INR response and consideration of the indication being treated. Typical maintenance doses are 2 to 10 mg once daily.</p>


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</table><p> </p>


<p>The genetic analysis and statements that appear in this app have not been evaluated by the United States Food and Drug Administration. The Sequencing.com website and all software applications (Apps) that use Sequencing.com's website, as well as Sequencing.com's open Application Programming Interface (API), are not intended to diagnose, treat, cure, or prevent any disease.</p><p>This DNA analysis app, and the report produced by this app, do not determine whether a medication is appropriate and they also do not provide medical advice or diagnose any medical conditions. You should not use this report to make treatment decisions. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medication or medical condition. Do not disregard professional medical advice or delay in seeking it because of this report. Any medical decisions should be made only after discussing the results with your health care provider. Your health care provider may determine that the results need to be confirmed using clinical pharmacogenetics testing.</p>


Medication and Drug Response

This report analyzes your DNA and provides insights into medication reactions and risk of drug addiction.