Prevent Breast Cancer

DNA Analysis for Breast Cancer Risk: BRCA1 and BRCA2 Analysis, Plus 8 Additional Genes

Predict, prevent, and prevail over breast cancer and ovarian cancer.

This DNA report analyzes your genes and provides insight about:

• Genetic risk of Breast Cancer
• Genetic risk of Breast Cancer with Radiation Exposure (such as from chest x-rays, CAT scans, and mammograms)
• Genetic risk of Ovarian Cancer

Comprehensive Analysis of Breast Cancer- and Ovarian Cancer-Related Genes

10 genes associated with breast and/or ovarian cancer are analyzed, including:

• BRCA1
• BRCA2
• BARD1
• ATM
• CHEK2
• PALB2
• PTEN
• TP53
• FGFR2
• TNRC9

Can I use the DNA test that I had with another company?

Yes, the Prevent Breast Cancer app can analyze DNA data from most genetic testing. For example, this app can analyze the raw data from 23andMe, AncestryDNA, and MyHeritage.

For the most comprehensive assessment of the 10 genes that increase the risk of breast cancer, including the BRCA1 and BRCA 2 genes, we recommend  Whole Genome Sequencing. Sequencing your entire genome means ~100% of the data for all of your genes, including BRCA1 and BRCA 2, will be obtained, and there will be no gaps in the data. Sequencing your whole genome is now even less expensive than tests that only obtain data on the BRCA1 and BRCA2 genes.

Our  Whole Genome Sequencing service includes both 30x whole-genome sequencing and this Prevent Breast Cancer analysis.

How reliable are the results?

All DNA analysis apps, including the Prevent Breast Cancer app, can analyze raw DNA data from most genetic tests. The analysis is dependent upon the quality of the raw DNA data that's generated by the genetic test.

Most of the common providers of DNA tests, such as 23andMe, AncestryDNA, and MyHeritage, provide high-quality genetic tests that generate high-quality raw DNA data. We have found, however, that the types of tests performed by 23andMe and similar companies, known as "genotyping tests," can sometimes generate a small amount of unreliable data points. (We're referring to the genotypic call for a genetic variant as a "data point.")

Whenever Sequencing.com identifies a data point in the raw DNA data file from a specific test to be potentially unreliable, our quality controls will proactively change that one data point to a no-call prior to it being analyzed by the app. This effetively removes that potentially unreliable data point when our DNA analysis apps analyze raw DNA data from that specific test. (Your raw DNA data file stored in your Sequencing.com account is never altered. Instead, this proactive quality control measure is only applied dynamically to the raw data immediately prior to it being analyzed by an app.) 

Please note that while we use strict quality control checks of the raw DNA data, these quality checks are not perfect and some unreliable data in the raw DNA data may still be analyzed by an app. This is why it is always important to discuss your DNA data and the results of DNA analysis with a healthcare professional, such as a genetic counselor or your healthcare provider.

Are common medical exams increasing my risk of breast cancer?

Some women (and men) have changes in their genes that increase their risk of breast cancer when exposed to radiation, such as during x-rays and mammograms.

If you or your child has these genetic changes, then it is important to avoid radiation to the chest throughout life.

What is the optimal age to use this app?

The fight against breast cancer starts with newborns.¹

• If a baby is found to be at increased risk of breast cancer, there are numerous preventions throughout childhood that can significantly decrease the risk of breast cancer throughout life.
• Useful preventions also exist for teens and women of all ages.

Is breast cancer prevention only for females?

The fight against breast cancer is not defined by gender.¹

Men and women can fight side-by-side against breast cancer and help protect themselves and future generations.

• About 1 percent of all breast cancers occur in men, with the number of new cases increasing each year.
• If a man has changes in genes associated with breast cancer, such as the BRCA1 and BRCA2 genes, he will have a significantly increased risk of prostate and testicular cancer.
• If a man finds he has an increased risk of breast, prostate, or testicular cancer, then instituting various preventions, such as early and more frequent screening exams, may be lifesaving.
• If a father finds out he has an increased risk of breast cancer, then his daughters may also be at risk.

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¹Outsmart Your Genes by Dr. Brandon Colby MD, Sequencing's Founder.

Interested in learning more about DNA testing for breast cancer risk and prevention? The chapter from Outsmart Your Genes that discusses going on the offensive in our war against breast and ovarian cancer is provided below for free.

Stay Up-To-Date on the Latest DNA Research

Our Education Center is updated each week with new genetic research and the latest technological advancements in the fields of genomics and personalized medicine. Interested in learning more? Check out the article on how to Outsmart Your Genes.