Prevent Breast Cancer

DNA Analysis for Breast Cancer Risk: BRCA1 & BRCA2 Analysis + 8 Additional Genes

Predict, prevent and prevail over breast cancer and ovarian cancer

This DNA report analyzes your genes and provides insight about:

• Genetic risk of Breast Cancer
• Genetic risk of Breast Cancer with Radiation Exposure (such as from chest x-rays, CAT scans, and mammograms)
• Genetic risk of Ovarian Cancer

Comprehensive Analysis of Breast Cancer and Ovarian Cancer-related Genes

10 genes associated with breast and/or ovarian cancer are analyzed including

• BRCA1
• BRCA2
• BARD1
• ATM
• CHEK2
• PALB2
• PTEN
• TP53
• FGFR2
• TNRC9

Can I use the DNA test that I had with another company?

Yes, the Prevent Breast Cancer app can analyze DNA data from most genetic testing. For example, this app can analyze the raw data from 23andMe, AncestryDNA, and MyHeritage.

For the most comprehensive assessment of the 10 genes that increase the risk of breast cancer, including the BRCA1/2 genes, we recommend whole genome sequencing. Sequencing your entire genome means ~100% of the data for all of your genes, including BRCA1/2, will be obtained and there will be no gaps in the data. Sequencing your whole genome is now even less expensive than tests that only obtain data on the BRCA1 and BRCA2 genes.

Our Ultimate Genome Sequencing service includes both 30x whole-genome sequencing and this Prevent Breast Cancer analysis.

How reliable are the results?

All DNA analysis apps, including the Prevent Breast Cancer app, can analyze raw DNA data from most genetic tests. The analysis is dependent upon the quality of the raw DNA data that's generated by the genetic test.

Most of the common providers of DNA tests, such as 23andMe, AncestryDNA, and MyHeritage, provide high-quality genetic tests that generate high-quality raw DNA data. We have found, however, that the types of tests performed by 23andMe and similar companies, known as 'genotyping tests', can sometimes generate a small amount of unreliable data points. (We're referring to the genotypic call for a genetic variant as a 'data point.')

Whenever Sequencing.com identifies a data point in the raw DNA data file from a specific test to be potentially unreliable, our quality controls will proactively change that one data point to a no-call prior to it being analyzed by the app. This effetively removes that potentially unreliable data point when our DNA analysis apps analyze raw DNA data from that specific test. (Your raw DNA data file stored in your Sequencing.com is never altered. Instead, this proactive quality control measure is only applied dynamically to the raw data immediately prior to it being analyzed by an app.) 

Please note that while we use strict quality control checks of the raw DNA data, these quality checks are not perfect and some unreliable data in the raw DNA data may still be analyzed by an app. This is why it is always important to discuss your DNA data and the results of DNA analysis with a healthcare professional, such as a genetic counselor or your healthcare provider.

Are common medical exams increasing your risk of breast cancer?

Some women (and men) have changes in their genes that increase their risk of breast cancer when exposed to radiation, such as during x-rays and mammograms.

If you or your child has these genetic changes then it is important that you avoid radiation to your chest throughout your entire life.

What is the optimal age to use this app?

The fight against breast cancer starts with newborns.¹

• If a baby is found to be at increased risk of breast cancer, there are numerous preventions throughout childhood that can significantly decrease the risk of breast cancer throughout life.
• Useful preventions also exist for teens and women of all ages.

Is breast cancer prevention only for females?

The fight against breast cancer is not defined by gender.¹

Men and women can fight side-by-side against breast cancer and help protect themselves and future generations.

• About 1 percent of all breast cancers occur in men, with the number of new cases increasing each year.
• If a man has changes in genes associated with breast cancer, such as BRCA1 and BRCA2, he will have a significantly increased risk of prostate and testicular cancer.
• If a man is found to have an increased risk of breast, prostate, or testicular cancer then instituting various preventions, such as early and more frequent screening exams, may be lifesaving.
• If a father finds out he has an increased risk of breast cancer then his daughters may also be at risk.

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¹Outsmart Your Genes by Brandon Colby MD

Interesting in learning more about DNA testing for breast cancer risk and prevention? Check out the section about going on the offensive in our war against breast and ovarian cancer in Outsmart Your Genes.

Stay Up-To-Date On The Latest DNA Research

Our new Education Center is updated each week with new genetic research the latest technological advancements in the fields of genomics and personalized medicine. Interested in learning more? Check out the article on how to Outsmart Your Genes.

This app analyzes your DNA and provides information about your genetic risk of breast cancer and ovarian cancer.

Once your DNA data is stored in your Sequencing.com account, after purchasing this DNA report simply click the app's 'Start' button and you'll receive your report in about 30 minutes.

If your DNA data is not already stored in your account, you can either import your data from a DNA test you've already taken (such as from 23andMe or AncestryDNA) or you can order one of our DNA tests.

You've already taken a DNA test	You need a DNA test
Upload your DNA data	Order a DNA test
Our Universal DNA Compatibility enables this app to work with DNA data from almost any genetic test including 23andMe, Ancestry, MyHeritage, FTDNA, and genome sequencing.	Our clinical-grade 30x Whole Genome Sequencing test obtains data on 100% of your genome.

The Prevent Breast Cancer DNA Report is compatible with data from almost all DNA tests and genome sequencing services.

This DNA analysis app is optimized for Sequencing.com's Ultimate Genome Sequencing service, which sequences the entire BRCA1 and BRCA2 genes.

What type of DNA data can I use with this app?

You can use DNA data from almost any genetic test. This includes:

• Whole genome sequencing and exome sequencing
• 23andMe, Ancestry.com, FamilyTreeDNA and MyHeritage
• Most DNA genotyping microarrays including Illumina Bead Arrays^®, Affymetrix Gene Chips^® and the Nexus Chip^®

Please note that the ability for this app to analyze breast cancer risk and ovarian cancer risk will depend upon the amount of genetic data in your genetic data file. If there is not enough genetic data in your file then some disease risk may not be able to be fully analyzed or may not be able to be analyzed at all. The results will indicate if this occurs. A file not containing enough data for full genetic analysis of cancer risk is more likely to occur if your genetic data file is from a company or laboratory that uses DNA microarray technology for their genetic testing, such as Ancestry.com, 23andMe and MyHeritage. 

Do I need to do anything to the file containing my genetic data before it is analyzed by this app?

Good news... the app does everything for you.

All you need to do is either upload or import the file containing your genetic data into your Sequencing.com account. Start the app, select the file and the app will handle do everything else.

23andMe data can be uploaded or imported directly from 23andMe (via the Upload Center) while Ancestry.com, Family Tree DNA and The Genographic Project data can be obtained from those services and then uploaded to your account at Sequencing.com. You don't need to do anything to the file you obtain from these services... just upload the file to your secure account at Sequencing.com and then you can use it to power most apps.

Both whole and exome sequencing data can be provided unaligned (such as in FASTQ or FASTA formats), aligned but without variant calling (such as BAM or SAM formats) or in VCF, CRAM or AVRO formats.

What about determining sex or reference genome used when the data was created?

Some more good news... the app does this as well. It utilizes an advanced automated approach to determine sex and reference genome (if the file format is downstream of alignment).

What do the question marks and dashes represent in the 'My Genetic Makeup' column of this table?

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The genetic analysis and statements that appear in this app and report have not been evaluated by the United States Food and Drug Administration. The Sequencing.com website and all software applications (Apps) that use Sequencing.com's website, as well as Sequencing.com's open Application Programming Interface (API), are not intended to diagnose, monitor, treat, cure, prevent nor alleviate any disease.

While this DNA analysis app can analyze data from many different types of genetic tests, it is important to take into consideration that the data from some types of genetic tests may not provide a complete assessment of your genetic risk of breast cancer. For example, if your DNA data is from a genotyping genetic test, which is the type of testing used by 23andMe, AncestryDNA, MyHeritage, FamilyTreeDNA, and Living DNA, then the analysis of your DNA data and the report provided by this app may not give you a complete understanding of your breast cancer risk, especially if breast cancer runs in your family.

It is also important to take into consideration that the quality of some of the raw data from some types of genetic tests may be unreliable. For example, a small percentage of raw data from genotyping genetic tests may be unreliable. The report provided by this app is based on the analysis of the raw data so if the raw data contains unreliable data, the app may have analyzed that unreliable data, and the report may include results based on that unreliable data.

If you think you may be at higher risk for breast cancer, it is best to work with a doctor or genetic counselor who can assess your risk, interpret your results, and build an action plan.