This DNA report analyzes your genes and provides insight about:
10 genes associated with breast and/or ovarian cancer are analyzed including
Yes, the Prevent Breast Cancer app can analyze DNA data from most genetic testing. For example, this app can analyze the raw data from 23andMe, AncestryDNA, and MyHeritage.
For the most comprehensive assessment of the 10 genes that increase the risk of breast cancer, including the BRCA1/2 genes, we recommend whole genome sequencing. Sequencing your entire genome means ~100% of the data for all of your genes, including BRCA1/2, will be obtained and there will be no gaps in the data. Sequencing your whole genome is now even less expensive than tests that only obtain data on the BRCA1 and BRCA2 genes.
Our Ultimate Genome Sequencing service includes both 30x whole-genome sequencing and this Prevent Breast Cancer analysis.
All DNA analysis apps, including the Prevent Breast Cancer app, can analyze raw DNA data from most genetic tests. The analysis is dependent upon the quality of the raw DNA data that's generated by the genetic test.
Most of the common providers of DNA tests, such as 23andMe, AncestryDNA, and MyHeritage, provide high-quality genetic tests that generate high-quality raw DNA data. We have found, however, that the types of tests performed by 23andMe and similar companies, known as 'genotyping tests', can sometimes generate a small amount of unreliable data points. (We're referring to the genotypic call for a genetic variant as a 'data point.')
Whenever Sequencing.com identifies a data point in the raw DNA data file from a specific test to be potentially unreliable, our quality controls will proactively change that one data point to a no-call prior to it being analyzed by the app. This effetively removes that potentially unreliable data point when our DNA analysis apps analyze raw DNA data from that specific test. (Your raw DNA data file stored in your Sequencing.com is never altered. Instead, this proactive quality control measure is only applied dynamically to the raw data immediately prior to it being analyzed by an app.)
Please note that while we use strict quality control checks of the raw DNA data, these quality checks are not perfect and some unreliable data in the raw DNA data may still be analyzed by an app. This is why it is always important to discuss your DNA data and the results of DNA analysis with a healthcare professional, such as a genetic counselor or your healthcare provider.
Some women (and men) have changes in their genes that increase their risk of breast cancer when exposed to radiation, such as during x-rays and mammograms.
If you or your child has these genetic changes then it is important that you avoid radiation to your chest throughout your entire life.
The fight against breast cancer starts with newborns.1
The fight against breast cancer is not defined by gender.1
Men and women can fight side-by-side against breast cancer and help protect themselves and future generations.
1Outsmart Your Genes by Brandon Colby MD
Interesting in learning more about DNA testing for breast cancer risk and prevention? Check out the section about going on the offensive in our war against breast and ovarian cancer in Outsmart Your Genes.
Our new Education Center is updated each week with new genetic research the latest technological advancements in the fields of genomics and personalized medicine. Interested in learning more? Check out the article on how to Outsmart Your Genes.
Once your DNA data is stored in your Sequencing.com account, after purchasing this DNA report simply click the app's 'Start' button and you'll receive your report in about 30 minutes.
If your DNA data is not already stored in your account, you can either import your data from a DNA test you've already taken (such as from 23andMe or AncestryDNA) or you can order one of our DNA tests.
You've already taken a DNA test
You need a DNA test
|Our Universal DNA Compatibility enables this app to work with DNA data from almost any genetic test including 23andMe, Ancestry, MyHeritage, FTDNA, and genome sequencing.||Our clinical-grade 30x Whole Genome Sequencing test obtains data on 100% of your genome.|
|Test Compatibility||Format Compatibility||Variant Compatibility||Reference Genome Compatibility|
|Whole Genome Sequencing||FASTQ and FQ||SNP / SNV
(Single Nucleotide Variants)
|hg38 / GRCh38|
|Exome Sequencing||FASTA and FA||hg19 / GRCh37|
|Ultimate DNA Test||BAM||hg18 / GRCh36|
|23andMe||SAM||hg17 / GRCh35|
|Dante Labs||Genome VCF (gVCF and GVCF)|
|Genes for Good||CSV|
|HomeDNA||gz and zip compressed files|
|FTDNA||almost all other genetic data formats|
|New Amsterdam Genomics|
|almost all other genetic tests|
Ultimate DNA Test
Ultimate Genome Sequencing
|Amount of genome tested||1%||100%|
|Technology||Enhanced Genotyping Microarray||Clinical-Grade 30x Genome Sequencing|
Silver Membership to Sequencing.com
(includes your choice of DNA analysis apps & reports)
Silver Membership to Sequencing.com
You can use DNA data from almost any genetic test. This includes:
Please note that the ability for this app to analyze breast cancer risk and ovarian cancer risk will depend upon the amount of genetic data in your genetic data file. If there is not enough genetic data in your file then some disease risk may not be able to be fully analyzed or may not be able to be analyzed at all. The results will indicate if this occurs. A file not containing enough data for full genetic analysis of cancer risk is more likely to occur if your genetic data file is from a company or laboratory that uses DNA microarray technology for their genetic testing, such as Ancestry.com, 23andMe and MyHeritage.
Good news... the app does everything for you.
All you need to do is either upload or import the file containing your genetic data into your Sequencing.com account. Start the app, select the file and the app will handle do everything else.
23andMe data can be uploaded or imported directly from 23andMe (via the Upload Center) while Ancestry.com, Family Tree DNA and The Genographic Project data can be obtained from those services and then uploaded to your account at Sequencing.com. You don't need to do anything to the file you obtain from these services... just upload the file to your secure account at Sequencing.com and then you can use it to power most apps.
Both whole and exome sequencing data can be provided unaligned (such as in FASTQ or FASTA formats), aligned but without variant calling (such as BAM or SAM formats) or in VCF, CRAM or AVRO formats.
Some more good news... the app does this as well. It utilizes an advanced automated approach to determine sex and reference genome (if the file format is downstream of alignment).
The genetic analysis and statements that appear in this app and report have not been evaluated by the United States Food and Drug Administration. The Sequencing.com website and all software applications (Apps) that use Sequencing.com's website, as well as Sequencing.com's open Application Programming Interface (API), are not intended to diagnose, monitor, treat, cure, prevent nor alleviate any disease.
While this DNA analysis app can analyze data from many different types of genetic tests, it is important to take into consideration that the data from some types of genetic tests may not provide a complete assessment of your genetic risk of breast cancer. For example, if your DNA data is from a genotyping genetic test, which is the type of testing used by 23andMe, AncestryDNA, MyHeritage, FamilyTreeDNA, and Living DNA, then the analysis of your DNA data and the report provided by this app may not give you a complete understanding of your breast cancer risk, especially if breast cancer runs in your family.
It is also important to take into consideration that the quality of some of the raw data from some types of genetic tests may be unreliable. For example, a small percentage of raw data from genotyping genetic tests may be unreliable. The report provided by this app is based on the analysis of the raw data so if the raw data contains unreliable data, the app may have analyzed that unreliable data, and the report may include results based on that unreliable data.
If you think you may be at higher risk for breast cancer, it is best to work with a doctor or genetic counselor who can assess your risk, interpret your results, and build an action plan.