Predict, prevent and prevail over breast cancer and ovarian cancer
This powerful app analyzes your genes and provides insight about:
- Genetic risk of Breast Cancer
- Genetic risk of Breast Cancer with Radiation Exposure (such as from chest x-rays, cat scans and mammograms)
- Genetic risk of Ovarian Cancer
Includes an analysis of 10 genes associated with breast and/or ovarian cancer.
- Genes analyzed: BRCA1, BRCA2, BARD1, ATM, CHEK2, PALB2, PTEN, TP53, FGFR2 and TNRC9.
Are common medical exams increasing your risk of breast cancer?
Some women (and men) have changes in their genes that increase their risk of breast cancer when exposed to radiation, such as during x-rays and mammograms.
If you or your child has these genetic changes then it is important that you avoid radiation to your chest throughout your entire life.
What is the optimal age to use this app?
The fight against breast cancer starts with newborns.1
- If a baby is found to be at increased risk of breast cancer, there are numerous preventions throughout childhood that can significantly decrease the risk of breast cancer throughout life.
- Useful preventions also exist for teens and women of all ages.
Only for females?
The fight against breast cancer is not defined by gender.1 Men and women can fight side-by-side against breast cancer and help protect themselves and future generations.
- About 1 percent of all breast cancers occur in men, with the number of new cases increasing each year.
- If a man has changes in genes associated with breast cancer, such as BRCA1 and BRCA2, he will have a significantly increased the risk of prostate and testicular cancer.
- If a man is found to have an increased risk of breast, prostate or testicular cancer then instituting various preventions, such as early and more frequent screening exams, may be lifesaving.
- If a father finds out he has an increased risk of breast cancer then his daughters may also be at risk.
1Outsmart Your Genes by Brandon Colby MD - Read the section about going on the offensive in our war against breast and ovarian cancer
To purchase this app:
- Log in to your Sequencing.com account.
- If you are already logged in, click the 'Add to Cart' button located under the app icon (top left of this page).
- This app will be added to your cart.
- Click the cart icon that appears in the top right header of the page and follow the instructions to purchase this app.
- This app will immediately be added to your My Apps page.
To use this app:
- Go to My Apps and click the 'Start App' button.
- Select the file that contains your genetic data.*
- Click the 'Submit' button
- The app will study your genes and create a report that's tailored to you.
- This app is speedy so most reports are ready within minutes! We'll send you an email when your report is ready.
*Upload your genetic data at the Upload Center. If you don't yet have genetic data, don't worry! You can use one of our fun sample genomes. Just start the app and select a sample genome.
*The ability for this app to analyze breast cancer risk and ovarian cancer risk will depend upon the amount of genetic data in your genetic data file. The app can only analyze data that was generated from your genetic test. Some tests may only provide some, but not all, data about breast cancer and ovarian cancer genes. If some data is missing, this app's analysis may not be complete. The results will indicate if any data was missing. A genetic data file may not contain enough data for full genetic analysis of cancer risk if your genetic data is from a company or laboratory that uses DNA microarray technology for their genetic testing, such as AncestryDNA, 23andMe, MyHeritage and Family Tree DNA.
|Whole Genome Sequencing (WGS)
|Genes for Good
||gz and zip compressed files
||almost all other genetic data formats
|Human Longevity Inc (HLI)
|almost all other genetic tests
What if I don't have genetic data?
You can still use this app. When you sign into the app for the first time you'll have the option to select from a list of sample genetic data if you don't have your own. All of the sample data are from real individuals so the analysis and results are real, too.
What types of genetic data can I use with this app?
You can use genetic data from almost any laboratory genetic test. This includes:
- Whole genome sequencing and exome sequencing
- 23andMe, Ancestry.com, Family Tree DNA and The Genographic Project (National Geographic)
- Most DNA genotyping microarrays including Illumina Bead Arrays®, Affymetrix Gene Chips® and the Nexus Chip®
Please note that the ability for this app to analyze breast cancer risk and ovarian cancer risk will depend upon the amount of genetic data in your genetic data file. If there is not enough genetic data in your file then some disease risk may not be able to be fully analyzed or may not be able to be analyzed at all. The results will indicate if this occurs. A file not containing enough data for full genetic analysis of cancer risk is more likely to occur if your genetic data file is from a company or laboratory that uses DNA microarray technology for their genetic testing, such as Ancestry.com, 23andMe and MyHeritage.
Do I need to do anything to the file containing my genetic data before it is analyzed by this app?
Good news... the app does everything for you.
All you need to do is either upload or import the file containing your genetic data into your Sequencing.com account. Start the app, select the file and the app will handle do everything else.
23andMe data can be uploaded or imported directly from 23andMe (via the Upload Center) while Ancestry.com, Family Tree DNA and The Genographic Project data can be obtained from those services and then uploaded to your account at Sequencing.com. You don't need to do anything to the file you obtain from these services... just upload the file to your secure account at Sequencing.com and then you can use it to power most apps.
Both whole and exome sequencing data can be provided unaligned (such as in FASTQ or FASTA formats), aligned but without variant calling (such as BAM or SAM formats) or in VCF, CRAM or AVRO formats.
What about determining sex or reference genome used when the data was created?
Some more good news... the app does this as well. It utilizes an advanced automated approach to determine sex and reference genome (if the file format is downstream of alignment).
What do the question marks and dashes represent in the 'My Genetic Makeup' column of this table?
Two question marks are used when your genetic data file did not contain any data on this specific genetic variant and therefore the data was not tested for and is 'Unknown'. Two question marks are used because each person's DNA contains two copies of that genetic variant so there is one question mark for each copy of the genetic variant in your DNA.
A single question mark will appear when your genetic data file did not contain any data on this specific genetic and DNA commonly only contains a single copy of that genetic variant.
For example, all variants on the mitochondrial chromosome (Chromosome "M") exist as a single copy because DNA only contains a single copy of the mitochondrial chromosome. This is different from most chromosomes, which appear duplicate (there are two copies of chromosome 1, two copies of chromosome 2, etc.). If the variant is on a chromosome that there is only a single copy of and there is no data on that variant in the data file then only a single question mark will appear.
Two dashes are used if your genetic data file does include information about this specific genetic variant but the data is a 'No Call.' A 'No Call' means the lab that generated the file determined that the variant's test result did not pass quality control. A 'No Call' may also appear when Sequencing.com's additional quality control determines a variant's result is not reliable and may provide inaccurate results. Sequencing.com has implemented this additional quality control to ensure that only the highest quality genetic data is analyzed by apps.
Two dashes are used instead of question marks because the genetic data file does contain data on that variant but the variant's results are not reliable.
A single dash is used when the variant's results are not reliable (ie the test result for that variant fails quality control) and DNA contains only a single copy of that variant. For example, all variants on the mitochondrial chromosome that are tested for by a genetic test but don't pass quality control have a single dash as the variant's result.
The genetic analysis and statements that appear in this app have not been evaluated by the United States Food and Drug Administration. The Sequencing.com website and all software applications (Apps) that use Sequencing.com's website, as well as Sequencing.com's open Application Programming Interface (API), are not intended to diagnose, treat, cure, or prevent any disease.