Cardiometabolic Health PRS

Curious about your genetic predisposition to common conditions like heart disease or type 2 diabetes? Traditional health assessments tell you part of the story, but your genes hold valuable clues. A Polygenic Risk Score (PRS) aggregates information from thousands of genetic differences to estimate your overall risk for developing certain health conditions. It's a new method helping clinicians understand genetic susceptibility.

The Problem with Traditional PRS Reports:

Did you know that many PRS reports are based mainly on genetic data from people of European ancestry? While valuable, this can mean:

• Less Accurate Results: PRS performance often decays with genetic distance from the training data, leading to diminished predictive accuracy in non-European populations.
• Exacerbating Health Disparities: Applying PRS developed primarily in one group to diverse populations can hinder risk stratification and potentially widen existing health disparities.
• Misleading Interpretation: Your PRS needs to be compared to your peer-population for a valid interpretation. Without ancestry-matched data, the results might be misleading.
   

Our Solution: Ancestry-Adjusted Cardiometabolic PRS!

Our service uses cutting-edge methods, including multi-ancestry models, to calculate your PRS. We explicitly consider your genetic ancestry to provide you with the most accurate and relevant risk estimate possible, regardless of your background. Our approach helps overcome the limitations of Eurocentric models.

What Our Cardiometabolic PRS Report Covers:

Our report provides genetic risk insights for important cardiometabolic conditions, which may include (based on current data and model availability):

1. Coronary Artery Disease (CAD)
2. Atrial Fibrillation (AF)
3. Hypertension (HTN)
4. Type 2 Diabetes (T2D)
5. Elevated Triglycerides (TG)
6. Elevated LDL-C ("Bad") Cholesterol Levels (LDL-C)
7. Decreased HDL-C ("Good") Cholesterol Levels (HDL-C)
8. Hypothyroidism (HT)
    

Key Benefits of Your Personalized Report:

Our ancestry-adjusted PRS report offers powerful benefits:

• Personalized Risk Insights: Get an estimate of your genetic predisposition to specific cardiometabolic conditions.
• More Accurate & Relevant: Our focus on ancestry-adjusted models means your results are more likely to be accurate for your specific genetic background, promoting meaningful risk assessment.
• Refined Understanding: PRS can help refine your understanding of your risk, even if you've had other genetic tests or have a family history.
• Empowerment: Genetic risk information can empower you to make informed decisions about lifestyle modifications.
• Inform Discussions with Your Doctor: Your results can be a starting point for conversations with your healthcare provider about potential tailored screening or prevention strategies.
   

Important Note: A PRS is a risk prediction tool and not a diagnostic test. It is one factor among many (including family history, lifestyle, and environment) that contributes to your overall cancer risk. Your results should be discussed with a healthcare professional for personalized interpretation and guidance.