MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
A TREX1 polymorphism, a V2 loop extension in gp120 and reduced replicative fitness in viremic non-progressors help explain differing speeds of HIV-1 disease.
Absent cerebral hemispheres replaced by fluid-filled sacs, alongside genital anomalies, call for physical examination, imaging and chromosomal microarray analysis.
L1CAM mutations on the X chromosome bring fluid buildup in the brain alongside obstruction-like bowel symptoms with no blockage. MRI, motility and DNA tests all help.
Persistently high eosinophil levels with no known cause define IHES. The page covers symptoms, diagnosis, FIP1L1-PDGFRA testing and options when imatinib fails.
Elevated prorenin, the precursor of renin, is often found by chance on blood tests in this inherited condition. The specific genes are not yet identified.
Diastolic readings that stay above 80 mm Hg strain the heart and vessels. Contributing factors, diagnosis and what genetic testing may add are set out.
Family history, first pregnancy, age over 30 and anemia all raise the odds of pregnancy-induced hypertension. Gene variants and the limits of testing are weighed.
Blood pressure that stays high despite several medicines defines resistant hypertension. The eNOS Glu298Asp polymorphism, testing and drug options are discussed.