Decoding the Mysteries of Hypogonadotropic Hypogonadism 10 without Anosmia
An intact sense of smell sets this form apart from Kallmann syndrome; hormone labs, MRI and testing of genes such as FGFR1 and SOX10 confirm HH10.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Hypotrichosis 3: CST6 Variants, Skin Signs and Carriers
Testing for a homozygous CST6 variant can confirm Hypotrichosis 3 and identify relatives who carry it without sparse hair, dry skin or impaired sweating.
Decoding Juvenile Polyposis of the Stomach: Understanding, Diagnosing, and Utilizing Genetic Testing
Benign stomach polyps tied to BMPR1A, PTEN and SMAD4 can bleed and carry gastric cancer risk; endoscopy, biopsy and gene testing shape surveillance and treatment.
Kuru and the PRNP G127V Resistance Variant
Prions passed on through funeral practices among the Fore people caused Kuru; carriers of the PRNP variant G127V are less likely to develop the disease.
Decoding the Genetics Behind Large for Gestational Age Babies
Birth weight above the 90th percentile defines LGA. Causes include maternal diabetes, obesity and genetic predisposition; testing can spot chromosomal changes.
Decoding LCHAD Deficiency and Maternal Acute Fatty Liver of Pregnancy: A Guide to Genetic Testing
Fetal LCHAD deficiency has been linked to acute fatty liver in the mother. Carrier screening, prenatal testing and newborn diagnosis are each explained.
Leigh Syndrome: Mitochondrial Complex I Deficiency
Muscle weakness, poor coordination, breathing problems and developmental delay follow complex I failure; MRI, lactic acid and NDUFS2 testing are used.
Leptin Dysfunction: Energy Balance and Gene Testing
When leptin is lacking or the body resists it, appetite and energy expenditure fall out of balance; lipodystrophy links are outlined too.