Expert Reviewed By: Dr. Brandon Colby MD
Hypertension, or high blood pressure, affects millions of people worldwide. It is a major risk factor for heart disease, stroke, and kidney failure. While there are many effective medications and lifestyle changes that can help control blood pressure, some individuals have a form of hypertension that is resistant to conventional therapy. This article will delve into the complexities of this condition, exploring the role of genetic testing in its diagnosis and management.
What is Hypertension Resistant to Conventional Therapy?
Hypertension resistant to conventional therapy, also known as resistant or refractory hypertension, is a condition in which a person's blood pressure remains high despite taking multiple medications and making lifestyle changes. According to a study, this complex condition has multiple contributing factors and requires thorough evaluation and tailored treatment approaches.
Genetic Factors in Resistant Hypertension
Research has shown that genetic factors may play a role in the development of resistant hypertension. One such factor is the Glu298Asp polymorphism in the endothelial nitric oxide synthase (eNOS) gene. A study found that this polymorphism may contribute to essential hypertension and resistance to conventional antihypertensive therapy. This highlights the potential use of genetic testing to better understand and manage resistant hypertension.
Identifying Genetic Risk Factors
Genetic testing can be used to identify the presence of the Glu298Asp polymorphism or other genetic risk factors associated with resistant hypertension. This information can help healthcare providers to better understand the underlying causes of a patient's high blood pressure and develop a more targeted treatment plan.
Personalizing Treatment Approaches
By identifying genetic risk factors, healthcare providers can tailor treatment approaches to the specific needs of patients with resistant hypertension. For example, certain medications may be more effective for individuals with specific genetic factors, while others may require alternative therapies. This personalized approach can lead to more effective blood pressure control and improved long-term health outcomes.
Recent Advances in the Treatment of Resistant Hypertension
As researchers continue to explore the complexities of resistant hypertension, new treatment options are emerging. One such advance is the use of dapagliflozin, a medication originally developed for the treatment of type 2 diabetes. A recent study found that dapagliflozin effectively reduces blood pressure, BMI, waist circumference, fasting glucose, and uric acid in obese patients with resistant hypertension and chronic kidney disease. This highlights the potential for innovative therapies to improve the management of this challenging condition.
Conclusion
Hypertension resistant to conventional therapy is a complex and multifactorial condition that requires a comprehensive understanding of the underlying causes and contributing factors. Genetic testing can play a crucial role in identifying genetic risk factors and personalizing treatment approaches for patients with this form of hypertension. As new research emerges, healthcare providers can continue to develop more effective strategies for managing resistant hypertension and improving the long-term health outcomes of those affected.
About The Expert Reviewer
Dr. Brandon Colby MD is a US physician specializing in the personalized prevention of disease through the use of genomic technologies. He’s an expert in genetic testing, genetic analysis, and precision medicine. Dr. Colby is also the Founder of and the author of Outsmart Your Genes.
Dr. Colby holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University’s Graduate School of Business, and a degree in Genetics with Honors from the University of Michigan. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC)