Medication and Drug Response Pharmacogenomics DNA Report

Pharmacogenomics genetic testing and analysis

Your DNA Report for Medication and Drug Reactions

Advanced Pharmacogenomics Analysis

The Medication & Drug Response DNA Report includes information about your risk of medication side effects with common medications as well as your risk of addiction to certain medications and illicit drugs.

The report includes:

  • Response to medications
  • Risk of harmful side effects
  • Risk of addiction
    • Alcohol
    • Nicotine
    • Marijuana / Cannabis
    • Cocaine
    • Opiates

Categories of medications included in the report:

  • Anticoagulants
  • Antidepressants
  • Asthma Treatment
  • Cardiovascular Disease Treatment
  • Neuropathic Pain Treatment
  • Type-2 Diabetes Treatment
  • Medications that have an Addiction Risk
  • Illicit Drugs

The complete list of medications and drugs is included in the 'List of Medications' tab.

 

Sample Report Pages

Pharmacogenomics Sample Report page 1

Pharmacogenomics Sample Report page 2

 

Learn More About Medication Reactions

Sequencing's Education Center includes several insightful articles about medication reactions. For example, you can learn about the effect of medicine on the body as well as how to reduce the side effects of medicine. Additional articles are added every week!

This report analyzes your DNA and provides insights into medication reactions and risk of drug addiction.

Once your DNA data is stored in your Sequencing.com account, after purchasing this DNA report simply click the app's 'Start' button and you'll receive your report in about 30 minutes.

If your DNA data is not already stored in your account, you can either import your data from a DNA test you've already taken (such as from 23andMe or AncestryDNA) or you can order one of our DNA tests.

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Our Universal DNA Compatibility enables this app to work with DNA data from almost any genetic test including 23andMe, Ancestry, MyHeritage, FTDNA and genome sequencing. Our clinical-grade 30x Whole Genome Sequencing test obtains data on 100% of your genome.

Powered by Universal DNA Compatibility technology, this genetic report is compatible with data from most DNA tests.

Use the Upload Center to upload your DNA data.

Test Compatibility   Format Compatibility   Variant Compatibility   Reference Genome Compatibility
Whole Genome Sequencing   FASTQ and FQ   SNP / SNV
(Single Nucleotide Variants)
  hg38 / GRCh38
Exome Sequencing   FASTA and FA       hg19 / GRCh37
Ultimate DNA Test   BAM       hg18 / GRCh36
23andMe   SAM       hg17 / GRCh35
AncestryDNA   CRAM        
MyHeritage   VCF        
Dante Labs   Genome VCF (gVCF and GVCF)        
Nebula Genomics   TXT        
Genes for Good   CSV        
Living DNA   TAB        
HomeDNA   gz and zip compressed files        
FTDNA   almost all other genetic data formats        
Silverberry Genomix            
Toolbox Genomics            
Full Genomes            
Color            
New Amsterdam Genomics            
24Genetics            
Vitagene            
Helix            
Genos            
tellmeGen            
GSA            
Axiom            
almost all other genetic tests

The pharmacogenomics analysis performed by this app is optimized for our DNA test and genome sequencing service

Compare to 23andMe, Ancestry and similar that test less than 0.1% of your genome.

 

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Learn how your DNA impacts your response to medications and drugs.

Medications

Metabolism of some medicines (Anti-ulcer, Anti-platelet, Antidepressant)

  • Common drugs such as Plavix, Omeprazole, Esomeprazole and more

Risk of addiction

  • Alcohol
  • Cannabis
  • Cocaine
  • Opiates including Heroin
  • Nicotine

Medications used to treat infections

  • Abacavir Hypersensitivity (HIV treatment)
  • Hepatitis C treatment response

Asthma treatment

  • Inhaled Glucocorticoids response
  • Salbutamol (Ventolin) response

Diabetes medications

  • Metformin Response (Type-2 Diabetes treatment)
  • Carbamazepine (Tegretol) Reaction (Neuropathic pain, epilepsy treatment) 

Heart medications

  • Statin Response
  • Warfarin (Coumadin) Dosing (Anticoagulant)

Medication to treat diseases common and rare diseases

  • NSAID Response (Inflammation, fever, pain treatment)
  • Aromatase Inhibitor Side-Effects (Breast cancer treatment)
  • Carbamazepine (Tegretol) Reaction (Neuropathic pain, epilepsy treatment)
  • Citalopram (Celexa) Response (Antidepressant)
  • Cyclophosphamide Reaction (Chemotherapy)
  • Sorafenib Response (Liver cancer treatment)

The following information is from the FDA's labeling information for Warfarin (Coumadin®).

Warfarin Dosing Recommendations with Consideration of Genetic Data

Table 1 below displays three ranges of expected maintenance COUMADIN doses observed in subgroups of patients having different combinations of CYP2C9 and VKORC1 gene variants [see Pharmacogenomics section 12.5].

If the patient’s CYP2C9 and/or VKORC1 genotype are known, consider these ranges in choosing the initial dose. Patients with CYP2C9 *1/*3, *2/*2, *2/*3, and *3/*3 may require more prolonged time (>2 to 4 weeks) to achieve maximum INR effect for a given dosage regimen than patients without these CYP variants.

Table 1: Three Ranges of Expected Maintenance COUMADIN Daily Doses Based on CYP2C9 and VKORC1 Genotypes †

VKORC1

CYP2C9

*1/*1

*1/*2

*1/*3

*2/*2

*2/*3

*3/*3

GG

5-7 mg

5-7 mg

3-4 mg

3-4 mg

3-4 mg

0.5-2 mg

AG

5-7 mg

3-4 mg

3-4 mg

3-4 mg

0.5-2 mg

0.5-2 mg

AA

3-4 mg

3-4 mg

0.5-2 mg

0.5-2 mg

0.5-2 mg

0.5-2 mg

† Ranges are derived from multiple published clinical studies. VKORC1 - 1639G>A (rs9923231) variant is used in this table. Other co-inherited VKORC1 variants may also be important determinants of warfarin dose.

Warfarin Dosing Recommendations without Consideration of Genetic Data

If the patient’s CYP2C9 and VKORC1 genotypes are not known, the initial dose of COUMADIN is usually 2 to 5 mg once daily.

Determine each patient’s dosing needs by close monitoring of the INR response and consideration of the indication being treated. Typical maintenance doses are 2 to 10 mg once daily.

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The genetic analysis and statements that appear in this app have not been evaluated by the United States Food and Drug Administration. The Sequencing.com website and all software applications (Apps) that use Sequencing.com's website, as well as Sequencing.com's open Application Programming Interface (API), are not intended to diagnose, treat, cure, or prevent any disease.

This DNA analysis app, and the report produced by this app, do not determine whether a medication is appropriate and they also do not provide medical advice or diagnose any medical conditions. You should not use this report to make treatment decisions on your own. Any medical decisions should be made only after discussing the results with your health care provider. Your health care provider may determine that the results need to be confirmed using clinical pharmacogenetic testing.