Isolated Ophthalmoplegia: Weak Eye Muscles, Double Vision
Paralysis or weakness of the eye-movement muscles can cause double vision and drooping eyelids; MRI and genetic testing help confirm isolated ophthalmoplegia.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Decoding the Fragile Framework: Understanding Osteogenesis Imperfecta, Mild
Blue sclera, hearing loss and repeated fractures point to Type I OI; COL1A1, COL1A2 and CREB3L1 findings can guide bisphosphonate use and reproductive planning.
Osteogenesis Imperfecta Type 1: What Testing Confirms
Bones that break with little force, blue sclera and hearing loss mark OI Type 1; COL1A1 and COL1A2 findings can confirm it, identify carriers and hint at severity.
Osteogenesis Imperfecta: PPIB, COL1A2 and IFITM5
Fragile bones that break easily trace back to variants such as a PPIB founder mutation in China, a COL1A2 missense change and IFITM5 mutations.
Osteogenesis Imperfecta Type III/IV: Genes and Diagnosis
Moderately severe brittle bone disease brings frequent fractures and deformities; COL1A1, COL1A2, IFITM5 and PPIB testing and whole exome sequencing are described.
Unraveling the Mysteries of Persistent Müllerian Duct Syndrome Type I: Genetic Testing and Its Applications
Males with PMDS type I retain Müllerian structures such as a uterus and fallopian tubes, and the condition is often found during surgery for undescended testes.
Unraveling the Mysteries of Persistent Müllerian Duct Syndrome Type II
Faults in the anti-Müllerian hormone receptor type II gene stop Müllerian ducts regressing in male fetal development, leaving cryptorchidism and inguinal hernias.
Decoding the Mystery: Understanding Pigmentary Retinopathy and Sensorineural Deafness
Dual sensory impairment combining retinal deterioration with inner-ear hearing loss has been tied to variants such as mitochondrial m.8340G>A and homozygous CDK10.