Decoding Neonatal Insulin-Dependent Diabetes Mellitus: A Guide to Genetic Testing
Mutations in ABCC8 and KCNJ11 disturb insulin secretion, causing high blood sugar within the first six months of life; testing separates NIDDM from type 1 diabetes.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Decoding the Mystery of Nephronophthisis-Like Nephropathy
Variants in XPNPEP3, ANKS6 and SLC41A1 have been tied to kidney damage resembling nephronophthisis, and the NPHPL1 locus links mitochondrial to ciliary dysfunction.
Decoding the Genetic Mysteries of Nevus Sebaceous
A waxy, yellow-orange plaque on the scalp is usually present at birth; biopsy confirms it, and a KRAS variant has been reported with epilepsy and skin tumors.
Nicotine Addiction: Which Genes Raise the Risk?
Variation in nicotinic acetylcholine receptor genes shapes susceptibility, and SNP analysis can flag people who may need targeted prevention or cessation support.
Decoding the Genetic Mysteries of Nicotine Dependence: A Comprehensive Guide
Genome-wide studies have linked new loci to dependence, while urinary nicotine metabolites and metabolism variants are studied as diagnostic biomarkers.
NSCLC: How Resistance to TKIs Develops and Is Detected
EGFR-mutant NSCLC often stops responding to tyrosine kinase inhibitors. Resistance routes such as T790M, NF1 and STC2 signaling and cfDNA testing are summarized.
EGFR Mutations in NSCLC and Response to TKI Therapy
Tyrosine kinase inhibitors are used in NSCLC when the tumor carries certain EGFR mutations. Selecting candidates, tracking resistance and PD-L1 levels are covered.
Unlocking the Mysteries of Oculomotor Apraxia: Genetic Testing and Beyond
Difficulty starting voluntary eye movements often prompts a head thrust. AOA2 stems from SETX mutations and ATLD1 from MRE11 mutations, found by DNA testing.