Plasma Triglyceride Levels: Genes, QTLs and Heart Risk
Measured by a lipid panel, blood triglycerides respond to diet, exercise and inherited factors; mapping quantitative trait loci helps explain that genetic contribution.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Decoding the Mystery of Acute Hepatic Porphyria: Understanding, Diagnosing, and Utilizing Genetic Testing
Abdominal pain, nausea and neurological symptoms follow a build-up of porphyrin precursors, and in the digenic form mutations in both HMBS and ALAD are involved.
Unraveling the Mystery of Progressive External Ophthalmoplegia, Proximal Myopathy, and Sudden Death
Shoulder, hip and eye muscle weakness together with the risk of sudden death can share a mitochondrial origin; testing names the mutation and flags at-risk kin.
Progressive Pulmonary Failure and Its PAH Gene Variants
Declining lung function here is linked to pulmonary arterial hypertension, with variants reported in BMPR2, ALK-1, ENG, SMAD4, CAV1 and KCNK3.
Decoding the Genetic Blueprint: Understanding Prostate Cancer, Somatic
Exome sequencing of prostate adenocarcinomas found recurrent MED12, FOXA1 and SPOP mutations, with SPOP marking a molecular subtype that can guide treatment.
Decoding the Genetic Mysteries of Prostate Cancer Susceptibility
Germline EGFR R831H, 2q37.3 mutations and ESR2 rs4986938 genotypes have all been tied to prostate cancer risk, alongside disparities in men of African descent.
Decoding Pseudoxanthoma Elasticum: Understanding the Role of Genetic Testing in Diagnosing and Managing Severity
A change in the ABCC6 gene calcifies elastic fibers in skin, eyes and blood vessels, and rare modifier variants can alter cardiovascular disease severity in PXE.
PVOD1: EIF2AK4 Mutations and Genetic Testing
EIF2AK4 mutations damage the lung blood vessels in autosomal dominant PVOD1, and next-generation sequencing can identify carriers before symptoms appear.