MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Pigment loss in skin, hair and eyes marks BOCA, a nonsyndromic form of albinism; exome and targeted sequencing pin down the melanin gene variants behind atypical cases.
Terminal complement component C6 builds the membrane attack complex, so a subtotal deficiency raises susceptibility to Neisseria meningitidis and prompts vaccination.
Too little myelin around nerve cells slows development and motor function; studies connect cerebral hypomyelination to YPEL3, Wwox, AIFM1 and MTHFS variants.
GALT enzyme deficiency lets galactose and its byproducts build up; newborn screening limits, GALT mutation analysis and a galactose-free diet are discussed.
How well clopidogrel blocks platelet aggregation varies with CYP2C19 and ABCB1 polymorphisms, plus age, smoking and interaction with proton pump inhibitors.
Clinical features alone rarely separate the cone-rod dystrophies, so AIPL1 testing by exome sequencing, gene panels or Sanger confirmation pins down this form.
Discover the role of genetic testing in diagnosing congenital ichthyosis, a rare genetic skin disorder, and how it can guide treatment strategies and inform family planning…
β-adrenergic receptor variants affect how people with congestive heart failure respond to beta-blockers, and the page weighs respiratory risks in COPD and asthma.