Understanding B Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3); KMT2A Rearranged
Rearrangements of the KMT2A gene on chromosome 11q23.3 drive this aggressive B-ALL subtype; FISH and PCR confirm it, inform prognosis and shape treatment.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Bardet-Biedl Syndrome 1 and BBS1 Cilia Dysfunction
Both parents carry a copy in this recessive subtype, where BBS1 mutations disrupt cilia; prenatal testing and carrier results inform family planning decisions.
Decoding the Genetic Mysteries of Bardet-Biedl Syndrome: A Comprehensive Guide
Discover the importance of genetic testing in diagnosing and managing Bardet-Biedl Syndrome, a rare genetic disorder affecting multiple organ systems. Learn about its symptoms,…
Benzene Toxicity: CYP2E1 and Susceptibility Testing
Workplace benzene exposure is tied to acute leukemia and to chromosome aberrations in lymphocytes, and a CYP2E1 variant has been proposed as a marker of susceptibility.
BMIQTL10 and BMI: What Genetic Testing Can Show
Quantitative trait loci are genome regions tied to measurable traits; for BMIQTL10 the page reviews a BDNF rs6265 study from North India and AutoQTL analysis.
BMIQTL9: A BMI Locus and What Testing Adds
Two studies frame BMIQTL9 here: a BDNF rs6265 analysis of 246 North Indian participants and a combined genome scan of five Finnish groups covering BMI and stature.
Breast and Ovarian Cancer Risk: The CanRisk Tool
Population-wide screening, genetic counseling and the CanRisk prediction tool each shape how inherited breast and ovarian cancer risk is assessed and acted on.
Breast Cancer Survival After Chemotherapy: Gene Markers
Survivin levels, a 16-gene subtyping scheme and NUSAP1 and KIAA0101 expression have each been tied to recurrence-free survival after neoadjuvant chemotherapy.