Low-Grade Astrocytoma: Mutations That Guide Care
Slow-growing grade I and II brain tumors are typed by molecular findings such as IDH, P53 and PML-NTRK2 changes, which inform treatment choice and monitoring.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Atherosclerosis Susceptibility: Genetic Risk Markers
Plaque buildup narrows arteries, and research points to markers such as the Sle1 interval and CD36 polymorphisms as contributors to inherited atherosclerosis risk.
Decoding the Mystery: Understanding Auditory Neuropathy Spectrum Disorder Through Genetic Testing
Speech can be hard to follow even when outer hair cells work normally. OAE and ABR results, plus OTOF or GJB2 findings, inform hearing aid and cochlear implant choices.
Unraveling the Mysteries of Autoimmune Polyglandular Syndrome Type 1 with Reversible Metaphyseal Dysplasia
Abnormal long bone development and growth delay can be the first clue to APS-1 in a child; dental enamel findings and AIRE sequencing bring the diagnosis forward.
Decoding the Genetic Mysteries of Azoospermia: A Comprehensive Guide
No sperm in the semen affects about 1% of men. Semen analysis confirms it, while chromosome studies and gene panels link RNF212 and STAG3 to meiotic arrest.
Unlocking the Mysteries of B Lymphoblastic Leukemia Lymphoma with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1)
Discover the importance of genetic testing in diagnosing and treating B Lymphoblastic Leukemia Lymphoma with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1).
B-ALL/NOS: PCM1-JAK2 Fusion Gene and Ruxolitinib
A PCM1-JAK2 fusion gene turns up in some cases of this aggressive B-cell blood cancer, and a case study reports a response to the JAK2 inhibitor ruxolitinib.
Understanding and Diagnosing B Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1
The Philadelphia chromosome fuses BCR and ABL1, and cytogenetics, FISH and PCR confirm it, guide targeted therapy and track fusion levels during treatment.