Tegafur Response: Genes Behind Chemotherapy Sensitivity
An oral chemotherapy drug used in colorectal, breast and stomach cancer, tegafur works unevenly; a map of 840 DNA-damage genes helps explain sensitivity and resistance.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Decoding the Enigma: Transient Myeloproliferative Disorder of Down Syndrome
Newborns with Down syndrome can develop TMD, an overgrowth of immature blood cells tied to GATA-1 mutations. Clinical signs, testing and the risk of AMKL are set out.
Unilateral Microphthalmos: What Genetic Testing Can Show
One underdeveloped eye marks this rare disorder. The page reviews the search for its genetic causes and both the benefits and the limits of testing.
Decoding the Mystery of Venous Thromboembolism Susceptibility: The Role of Genetic Testing
Factor V Leiden and prothrombin gene mutations, high altitude and chronic kidney disease all appear in research on who is more likely to develop venous thromboembolism.
ABCA1 Polymorphism and Cardiovascular Disease Risk
Because ABCA1 moves cholesterol out of cells, variants have been studied in coronary artery disease and atherosclerosis; PCR or genotyping arrays detect them.
Abnormal Finger Morphology: Testing and Screening
Hand examination and X-rays come first, then DNA analysis for mutations behind short, bent, fused or webbed fingers, including prenatal testing.
Unlocking the Secrets of Lung Adenocarcinoma: Genetic Testing and Tyrosine Kinase Inhibitors
EGFR mutations drive many lung adenocarcinomas and can be detected by PCR, NGS or FISH; the page explains how afatinib, erlotinib and gefitinib target them.
Unlocking the Mystery of Adult Hypophosphatasia: Genetic Testing as the Key
Unexplained musculoskeletal pain with a low alkaline phosphatase level can point to HPP in adults; ALPL testing confirms it and guides care.