Crohn's Disease-Associated Growth Failure: Genetics
Children and adolescents with Crohn's disease can develop growth failure, and research links complement factor B, mucus defects and immune tolerance genes to its risk.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Decoding Atypical Nephropathic Cystinosis: A Comprehensive Guide to Understanding, Diagnosing, and Genetic Testing
Milder symptoms and a later onset make this form of cystinosis hard to recognize, and white-cell cystine levels can be ambiguous, so CTNS testing confirms it.
Decoding Darier Disease: Acral Hemorrhagic Type and the Role of Genetic Testing
Painful, bleeding lesions on the hands and feet set this variant apart, and ATP2A2 testing confirms Darier disease and separates it from Hailey-Hailey disease.
Decoding the Mysteries of Lewy Body Dementia: A Genetic Perspective
The third most common cause of dementia is tied to APOE, GBA and SNCA variants affecting α-synuclein, amyloid and tau; ceramide metabolism may yield biomarkers.
Decoding Desmoid Disease: A Deeper Dive into Genetic Testing for Hereditary Conditions
About 5 to 15% of desmoid cases are inherited, tied to APC mutations that also cause familial adenomatous polyposis and carry a 50% chance of passing to a child.
Unlocking the Mysteries of Autosomal Recessive Neurohypophyseal Diabetes Insipidus
An AVP gene mutation leaves the body short of vasopressin, disrupting water balance; MRI and DNA testing confirm the recessive form, treated with desmopressin.
Unlocking the Mystery: Understanding and Diagnosing Drug-Induced Liver Injury Due to Flucloxacillin
Carrying HLA-B*5701 raises the risk of liver injury from the antibiotic flucloxacillin, alongside additional HLA alleles, female sex and polygenic risk scores.
Dystonia 32 (Cervical Dystonia): Causes and Testing
Cervical dystonia, as the page names it, has been tied to thyroid disease, immune measures, head trauma, stroke and encephalitis as well as to genetic factors.