Decoding the Mystery of Bone Mineral Density Abnormalities: A Genetic Perspective
Osteopenia and osteoporosis both raise fracture risk; a DXA scan returns a T-score, and variants linked to serum calcium help explain inherited risk.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Cardiovascular System Morphology: Genetic Testing
Structural changes in the heart and blood vessels may be congenital or acquired; karyotyping and FISH detect Klinefelter syndrome, gene panels Marfan.
Decoding the Mysteries: Understanding, Diagnosing, and Using Genetic Testing for Abnormalities of the Female Genitalia
Causes range from Klinefelter syndrome and congenital adrenal hyperplasia to XX/XY chimerism; genetic testing identifies which one and guides treatment.
Decoding the Mystery: Understanding Abnormality of the Immune System
Autoimmune disease, immunodeficiency and hypersensitivity reactions are the three patterns covered, with blood tests, imaging and genetic testing used in diagnosis.
Decoding the Enigma: Abnormality of Immune System Physiology
Misfiring immune responses show up as autoimmune disease, immunodeficiency or allergy; DNA analysis helps name mutations, weigh risk and choose medication.
Decoding Abnormalities of Iron Homeostasis: Genetic Testing and Beyond
Iron deficiency anemia, anemia of chronic disease and hereditary hemochromatosis are compared using hepcidin and ferritin markers and HFE and IREB2 gene testing.
Cracking the Code: Understanding and Diagnosing Abnormality of Lysosomal Metabolism
A missing lysosomal enzyme lets waste build up inside cells, as in Gaucher, Fabry and Pompe disease; carrier, prenatal and newborn screening options are set out.
Understanding, Diagnosing, and Using Genetic Testing for Abnormality of Metabolism/Homeostasis
Phenylketonuria, galactosemia and glycogen storage disease illustrate disorders of nutrient processing, with carrier testing and newborn screening.