Oncology Genetic Guide

Unlock Personalized Insights Into Cancer Treatment

Your DNA holds important clues about how you may respond to cancer therapies.

The Oncology Genetic Guide goes beyond one-size-fits-all treatment by revealing how your germline genetics can influence the way your body processes certain cancer medications. By combining pharmacogenetic research with clinical guidelines where available, this report helps you and your care team consider safer dosing and treatment adjustments.

What You’ll Discover

How Your Body Processes Cancer Drugs

Key genes such as DPYD, TPMT, and NUDT15 play a major role in how you metabolize chemotherapy. Variants in these genes can increase the likelihood of side effects like neutropenia or myelosuppression, while others may indicate a safer or more effective response.

Treatment Effectiveness and Outcomes

Certain genetic variants have been studied for possible influence on drug response or clearance. For example, research has explored ABCB1, MTHFR, CYP2D6, and CYP3A5, though clinical guidance is limited and these findings are considered research-grade.

Broad Coverage of Cancer Therapies

The guide provides insights across many commonly used oncology medications, including:

• Antimetabolics (capecitabine/fluoropyrimidines ↔ DPYD; thiopurines ↔ TPMT/NUDT15)
• Hormonal therapies (tamoxifen ↔ CYP2D6)
• Other medications (e.g., methotrexate, cytarabine, taxanes)

Inside the Report

• Clear Gene–Drug Insights: An explanation of how your DNA may impact medication safety, dosing, and response.
• Focus on Key Genes: In-depth analysis of high-impact variants like DPYD, NUDT15, TPMT, and CYP2D6. Additional genes (e.g., CYP3A5, MTHFR) are included as research-grade insights.
• Evidence-Based Guidance: Where formal guidance or labeling exists (e.g., CPIC/DPWG; FDA/EMA), results are mapped accordingly. Other findings are presented as research-grade.

Why It Matters

Cancer therapy is complex, and no two patients respond the same way. While some tolerate treatment well, others face serious side effects or limited results. Genetics is one of the reasons that may help explain these differences.

By uncovering your pharmacogenetic profile, this guide provides valuable context to guide conversations with your oncologist. It highlights where standard dosing may be safe and effective, and where adjustments or alternative options might be worth considering.

Reliable and Research-Driven

Every result is grounded in current scientific knowledge, with references to clinical guidelines and published studies. The Oncology Genetic Guide doesn’t replace medical care, but it equips you and your healthcare team with information that can make treatment more personal. Do not start, stop, or change any cancer treatment based on this guide without your oncologist’s guidance.

Take the Next Step

Your DNA offers more than a diagnosis, it’s a tool for smarter, safer treatment. With the Oncology Genetic Guide, you can approach your cancer journey with greater clarity and confidence.