DNA Data Viewer | Explore Genetic Data | Compatible With All Raw DNA Data

Data Viewer

Discover, Learn and Explore Your Genome

Data Viewer is the world' first browser and search engine designed for your genetic data.

New! Enhanced compatibility with all genetic data variants including:

  • SNPs / SNVs (Single Nucleotide Polymorphisms / Variants)
  • INDELs (Insertion and Deletion Variants)
  • CNVs (Copy Number Variations)
  • SVs (Structural Variations)
  • MITO (Mitochondrial Heteroplasmy)

 

Explore the association between your genetic data and diseases, conditions, traits and medication reactions.

Works with DNA data from any genetic testing including

  • whole genome sequencing (Dante Labs, Nebula Genomics, Veritas, GeneDx)
  • exome sequencing (Ambry Genetics, LabCorp, Quest)
  • arrays (23andMe, AncestryDNA, FamilyTreeDNA, MyHeritage, Living DNA, GSA, etc.)

 

It's easy to upload your raw DNA data for use with Data Viewer.

  1. Go to the Upload Center and choose one of the options to upload or import your DNA data files into your Sequencing.com account.
    • Skip this step if your genetic data is already stored in your account.
  2. Start this app by pressing the 'Start' button.
  3. Select the raw DNA data file stored in your account and press 'Submit'.

Free

Powered by Sequencing.com's Universal Compatibility technology, this app is compatible with data from all DNA tests.

 

Test Compatibility Format Compatibility Variant Compatibility
Whole Genome Sequencing (WGS) FASTQ SNP / SNV (Single Nucleotide Variant)
Exome Sequencing FASTA INDEL (Insertion Deletion Variant)
Nebula Genomics BAM SV (Structural Variations)
Dante Labs SAM CNV (Copy Number Variations)
23andMe CRAM MITO (Mitochondrial Heteroplasmy)
AncestryDNA VCF  
MyHeritage GVCF (genome VCF without blocks)  
Genes for Good gVCF (genome VCF with blocks)  
Living DNA TXT  
HomeDNA CSV  
FTDNA TAB  
Silverberry Genomix gz and zip compressed files  
Toolbox Genomics almost all other genetic data formats  
Veritas Genetics    
24Genetics    
Vitagene    
Helix    
Genos    
tellmeGen    
GSA    
Axiom    
almost all other genetic tests

 

Simple to use:

  1. Upload the genetic data file into your Sequencing.com account.
  2. Purchase and start this app.
  3. Select the genetic data file you want to view and the data will load in your Data Viewer.

You can also access the Data Viewer for files stored in your account by going to your My Files page and clicking on the filename.

Data Viewer Plus provides additional information relating to diseases, conditions, traits and medication reactions.

 
Upgrading to Data Viewer Plus is $4.99 per file
  • You can then use Data Viewer Plus with that file as often as you want for one year.
 
To upgrade to Data Viewer Plus
  • Start this app (the free version of Data Viewer)
  • Once your data loads in your Data Viewer, click the option to upgrade to the Plus version
 

Data Viewer vs Data Viewer Plus

Data Viewer is free and provides technical details about your genetic data. Each genetic variant (also referred to as SNP, SNV, DIP or InDel) from your file is listed on its own row along with the bioinformatic-related data about the variant (such as the gene, chromosome number, position on the chromosome, amino acid change (if there is one), etc. 
 
Data Viewer Plus provides all the information available in the free Data Viewer as well as information about diseases, traits, medication reactions and scientific studies. Data Viewer Plus includes:

Condition

the disease, trait or medication reaction associated with the genetic variant

Interpretation

an indication of whether all available scientific studies and clinical data support the association between the variant and the condition

'Pathogenic' and 'Likely Pathogenic' indicate support for the association

'Benign' and 'Likely Benign' indicate that the variant may not be associated with the condition

Review Status

an indication of the amount of confidence for the Interpretation

Four stars = highest confidence that the Interpretation is correct

Half of one star = lowest confidence that the Interpretation is correct

this usually occurs when there is only one study about the association between the variant and the condition and therefore the Interpretation is based only on a single study

References

clickable link to each journal article that has been published about the association between the variant and the condition

Links

clickable links that take you directly to additional information (SNPedia and ClinVar) for each variant

Have a question about your data? Ask an expert!

Genetic Counseling app icon by DNAFeed provides access to licensed professionals and experts to ask any questions about DNA data, genome data, gene tests and results from 23andMe, Ancestry, MyHeritage, FamilyTreeDNA FTDNA, Dante Labs, Helix & LivingDNA.

The new Genetic Counseling app ensures you always have access to an expert. The app works on any mobile device or computer and provides 30 days of unlimited, secure online chat with a licensed genetic counselor or geneticist.

When you use the app, with a single click you can provide the Genetic Counselor with secure access to your DNA data file stored in your Sequencing.com account. You can also easily provide access to any app results you want to discuss, including your Data Viewer.

Sequencing.com, and the Genetic Counseling app, are both confidential and HIPAA-compliant so your data remains safe.

What data can be viewed with Data Viewer?

The data viewer allows you to view almost all types of genetic data including data from whole genome sequencing, exome sequencing and DNA microarrays. This includes genetic data files provided by laboratories and companies such as 23andMe, Ancestry.com, MyHeritage, Genes for Good, Family Tree DNA, Dante Labs, Genomics Personalized Health and Illumina.
 
 

Do I have to convert my data into a specific format before using Data Viewer?

Data Viewer is already compatible with the format that your genetic data is already in. You do not need to convert your files and instead Data Viewer. Sequencing.com's unique Universal Data Compatibility technology enables all genetic data formats to be fully compatible with Data Viewer.
 
 

Will I be able to understand the genetic data that appears in Data Viewer and Data Viewer Plus?

Data Viewer and Data Viewer plus are designed for people who are comfortable interpreting their own raw genetic data. Interpreting your own data can become technical at times so it isn't for everyone.
 
If you find the data difficult to understand or simply want to learn actionable information about your genes, there are a wide range of apps in the marketplace in the Wellness, Nutrition, Fitness, and similar categories. These apps are designed to provide clear solutions for optimizing wellness and lifestyle.
 
 

How can I get assistance understanding my genetic data? Is there anyone I can ask?

Yes, assistance is available from a certified genetic counselor. To speak with a genetic counselor, please use the Genetic Counseling app.
 
 

What's the difference between Data Viewer and Data Viewer Plus?

For information about Data Viewer Plus, please click on the 'Data Viewer Plus' tab on this page.
 
 

Why are genes or genetic variants missing?

When viewing Data Viewer (and Data Viewer Plus), only the raw data contained within your genetic data file is displayed. If a gene wasn't tested for then data on that gene won't be displayed. This doesn't mean you don't have that gene, just that the genetic test that was performed didn't provide results for that gene, which is why the genetic data file didn't contain any data on that gene.
 
This can occur because some types of genetic tests, such as those performed by Ancestry.com, 23andMe, MyHeritage and similar companies only test a part of your genome, not your whole genome. Testing your whole genome, which means sequencing all of your genetic data (called 'Whole Genome Sequencing'). Only whole genome sequencing will provide data on all of your genes. If you're interested in Whole Genome Sequencing, this service is provided by several of Sequencing.com's Preferred Provider's of Genetic Testing.
 
 

Why is there missing data for some genetic variants?

If information appears to be missing from a row then this means the information doesn't exist for that specific variant.
 
For example, a variant may exist within a gene and therefore the 'Gene' column will be blank. Another variant may not have any known condition associated with it and therefore the 'Condition', 'Interpretation, 'Review Status' and 'References' columns will be blank.
 
 

When I search for a gene, why do the results show a different gene?

Most gene names have aliases (also known as synonyms). For example, the BRCA1 gene is also known as BRCC1, BROVCA1, FANCS, PNCA4, PSCP and RNF53. Each of those names is an alias for the same gene. This can get pretty confusing!

Data Viewer takes this into consideration and makes it easy to search using any alias. Simply search for any alias the gene is known by and Data Viewer will always know what gene you are referring to.

For example, if you search for FANCS, Data Viewer will know this is the same as the BRCA1 gene. The search results will show all of your data that's associated with the BRCA1 gene.

It's also important to point out that if you search for FANCS, the results will not show 'FANCS' in the Gene column. Instead, BRCA1 will appear. This is because BRCA1 is the most widely used name for this gene. (The most widely used gene name is also known as the HGNC Approved Gene Symbol.)

So if you search for a gene and a different gene name appears, it's because each name is an alias for the same gene. You can verify gene aliases at HGNC's GeneNames.org.

 

Why does Data Viewer show data that I can't find in my data file?

Some data files may not contain a rsid (also known as a rs#) for a variant. Instead, the file may identify the variant simply by it's chromosomal coordinate or the file may use an alternative identification system. Data Viewer is very advanced and if a data file does not include a rsid for a variant, Data Viewer will try to add this information.

For example, 23andMe files identify some variants by an i# instead of a rsid. While the i# is an ID system used only by 23andMe, the rsid is the ID used by all scientists throughout the world. Because the rsid is universally recognized as the standard nomenclature for variant identification, Data Viewer will always try to indicate the rsid for a variant even if the original data file doesn't include the rsid.

While Data Viwer always tries to assign a rsid to a variant, sometimes this is not possible. For example, a rsid may not appear for a variant because a rsid has not yet been established for that specific variant.

 

If I see a disease listed, does it mean I'm at risk for that disease?

When the Data Viewer Plus lists a condition (disease, trait, medication reaction, etc.), it doesn't necessarily mean you have a risk for it. Instead, it only means that the specific genetic variant listed in that row has been associated in scientific research with that condition. Whether your genetic data indicates that you are at risk of that condition will depend upon the interpretation of your raw genetic data. (Your raw genetic data does appear in that table and is listed in the 'Genotype' column.)

For example, if variant rs123 is associated with Cystic Fibros, anytime data contain genetic testing results for rs123, even if the results indicate no-risk, Data Viewer will include rs123 and that it is associated with the condition 'Cystic Fibrosis.' On a technical level, if rs123 has reference allele C and alternative allele T then this means that Cystic Fibrosis risk is likely associated with the "T" allele. If the genetic testing results shown in the 'Genotype' column is 'CC' then there is no risk of Cystic Fibrosis due to variant rs123. But if the Genotype column is 'CT' or 'TT' then there may be a risk of Cystic Fibrosis.

Need assistance understanding your raw genetic data? Use the Genetic Counseling app to speak with a genetic counselor.

 

The word 'Pathogenic' appears in the 'Interpretation' column of my Data Viewer. Does this mean I'm at risk for the condition?

Data Viewer does not perform any analysis about whether you do or do not have a risk for a condition. Because of this, Data Viewer will not state that you are or are not at risk for any condition. Only the apps in the 'Health' category of the App Market provide analysis as to whether you are likely to be at increased risk of a condition.

When it appears in Data Viewer, the term 'Pathogenic' is determined only by the variant, not by your genetic data. Everyone's Data Viewer that lists that same variant will always show the same data in the interpretation column.

For example, if person A and person B both take 23andMe's DNA test and then they both use Data Viewer to explore their DNA data, they will have the same list of genetic variants (because 23andMe performs the same test for everyone). While the results for each genetic variant will be unique between person A and person B, the list of variants will be exactly the same.

Since person A and person B will have the same list of variants, they will also have the same information in the 'Interpretation' column of their data viewer. This is because the information in the Interpretation column is associated with the variant.

If 'Pathogenic' appears in the Interpretation column, this is because researchers have identified the variant as being associated with the condition. This is why the term 'Pathogenic' is used. The term Pathogenic does not mean that you have the variant or that this variant is harmful to your health.

The word 'Interpretation' and all the terms in that column such as 'Pathogenic' are official terms obtained directly from the NIH's ClinVar database. Please see the table at the end of this section for more information about the meaning of the terms in the Interpretation column.

Need assistance understanding your raw genetic data? Use the Genetic Counseling app to speak with a genetic counselor.

 

Why is my SV (Structural Variations) VCF incompatible?

SVs are very complex genetic variations. Sequencing.com is compatible with the most modern way of representing SVs in a VCF file. If your SV file is not compatible with Data Viewer, it is most likely because your the file was produced using an alternative data structure.
 
For example, we've identified SV VCFs generated by Dante Labs with 'WGZ' in the filename, such as *.wgz.sv.vcf.gz, use an alternative data structure to represent SVs. Because of this, most SV files with WGZ in the filename was incompatible with Data Viewer.
 
We have good news! If your SV is incompatible with Data Viewer, we'll generate a new, SV VCF for you, for free. Your new SV VCF will have the most modern data structure, which means it will be compatible with Sequencing.com.
 
To request a new SV VCF, please upload your paired fastq (two FASTQ files) or your BAM file into your Sequencing.com account using Big Yotta, our secure desktop uploader for large file. After your FASTQs or BAM are stored in your account, please email support with the name of your file(s) and your request for a modern SV VCF to be generated. We'll create the new SV VCF for you and upload it into your account.
 
Please note that if you don't already have your FASTQ or BAM files, please contact the laboratory that performed your sequencing and request these files be provided. If they give you download links then simply sign into your Sequencing.com and submit the download links in the 'Import From Cloud' section of the Upload Center.
 
 

Why does my data sometimes reload when I access Data Viewer again?

Sequencing.com's Bioinformatics Team releases updates to Data Viewer on a weekly basis. Some of these updates require the genetic data from your file to 'reload' in your Data Viewer. Reloading of your data in Data Viewer ensures that you always benefit from the most up-to-date version of Data Viewer.
 
Reloading of data in your Data Viewer is both free and fully automated. It will occur only if there has been an update since the last time you accessed your file's data using your Data Viewer.
 
 

Definitions of the values in the 'Interpretation' column.

Interpretation Value Additional Information
Benign As recommended by ACMG/AMP for variants interpreted for Mendelian disorders.
Likely benign As recommended by ACMG/AMP for variants interpreted for Mendelian disorders.
Uncertain significance As recommended by ACMG/AMP for variants interpreted for Mendelian disorders.
Likely pathogenic As recommended by ACMG/AMP for variants interpreted for Mendelian disorders.
Pathogenic

As recommended by ACMG/AMP for variants interpreted for Mendelian disorders.

Variants that have low penetrance may be submitted as "Pathogenic"; please also include information about the penetrance in a "Comment on clinical significance".

drug response A general term for a variant that affects a drug response, not a disease. We anticipate adding more specific drug response terms based on a recommendation by CPIC.
association For variants identified in a GWAS study and further interpreted for their clinical significance.
risk factor For variants that are interpreted not to cause a disorder but to increase the risk.
protective For variants that decrease the risk of a disorder, including infections.
Affects For variants that cause a non-disease phenotype, such as lactose intolerance.
conflicting data from submitters Only for submissions from a consortium, where groups within the consortium have conflicting intepretations of a variant but provide a single submission to ClinVar.
other If ClinVar does not have the appropriate term for your submission, we ask that you submit "other" as clinical significance and contact us to discuss if there are other terms we should add.

not provided

For submissions without an interpretation of clinical significance. The primary goal of ClinVar annotations within Data Viewer Plus is to archive reports of clinical significance of variants. Therefore submissions with a clinical significance of "not provided" should be limited to:

  • "literature only" submissions that report a publication about the variant, without interpreting the clinical significance
  • "research" submissions that provide functional significance (e.g. undetectable protein level) but no interpretation of clinical significance
  • "clinical testing" or "phenotyping only" submissions from clinics or physicians that provide additional information about individuals with the variant, such as observed phenotypes, but do not interpret the clinical significance
Landrum MJ, Lee JM, Benson M, Brown GR, Chao C, Chitipiralla S, Gu B, Hart J, Hoffman D, Jang W, Karapetyan K, Katz K, Liu C, Maddipatla Z, Malheiro A, McDaniel K, Ovetsky M, Riley G, Zhou G, Holmes JB, Kattman BL, Maglott DR. ClinVar: improving access to variant interpretations and supporting evidence. Nucleic Acids Res. 2018 Jan 4. PubMed PMID: 29165669.

The genetic analysis and statements that appear in this app have not been evaluated by the United States Food and Drug Administration. The Sequencing.com website and all software applications (Apps) that use Sequencing.com's website, as well as Sequencing.com's open Application Programming Interface (API), are not intended to diagnose, treat, cure, or prevent any disease.

4.9 18725