Hemoglobin E Disease: Symptoms and Why Severity Varies
Common in Southeast Asia, this beta-globin variant may cause mild hemolytic anemia, weakness and an enlarged spleen; severity shifts when thalassemia is co-inherited.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Hereditary Hemorrhagic Hazards: Understanding Hemorrhagic Disease Due to Alpha-1-Antitrypsin Pittsburgh Mutation
One rare change to the alpha-1-antitrypsin protein turns a lung-protecting enzyme into one that disrupts clotting, so carriers can be identified before bleeding starts.
Harnessing Genetics: Understanding Hereditary Cancer-Predisposing Syndrome
Testing can pinpoint BRCA1, BRCA2 and other mutations behind HCPS, guiding closer screening, lifestyle changes or preventive surgery for people at raised cancer risk.
Hereditary Episodic Ataxia: Harnessing Genetic Testing for Better Diagnosis and Management
Episodes of poor coordination, dizziness and unsteadiness may follow stress or fatigue; DNA testing pinpoints the mutations behind hereditary episodic ataxia.
Hereditary Motor and Sensory Neuropathy: Unveiling the Genetic Mysteries with Modern Testing
Known also as Charcot-Marie-Tooth disease, HMSN damages peripheral nerves; compound heterozygous DST mutations affecting BPAG1 cause the axonal form.
Hereditary Sensory and Autonomic Neuropathy: Unraveling the Genetic Threads of a Complex Disorder
Loss of pain and temperature sensation, with autonomic effects on heart rate and digestion, marks HSAN; a WNK1 variant was reported in type IIA.
Hereditary Mysteries: Understanding Huntington Disease-Like Syndrome
Disorders that copy the movement, cognitive and psychiatric features of Huntington's Disease can stem from PRNP, JPH3 or TBP mutations, or from acquired causes.
Harnessing Genetic Testing to Unravel the Mysteries of Hydrops Fetalis
Fluid gathering in two or more fetal compartments is non-immune in about 90% of cases; whole-exome sequencing can find variants behind it and shape prenatal management.