Decoding C3 Deficiency: Unraveling the Genetic Mysteries of a Rare Disease
People with C3 gene mutations make too little complement component 3, which brings recurrent respiratory and urinary infections, lupus, vasculitis and kidney problems.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Decoding Canavan Disease: Understanding Familial Forms and the Power of Genetic Testing
A shortage of the enzyme aspartoacylase lets N-acetylaspartate build up in the brain, and the recessive disease is more common in Ashkenazi Jewish families.
Carboxymethyl-Dextran-A2-Gadolinium-DOTA: Testing Uses
Presented here as a rare disease, carboxymethyl-dextran-A2-gadolinium-DOTA is discussed through diagnostic, carrier, prenatal and preimplantation genetic testing.
Carcinoma of the Head of the Pancreas: Risk Genes
Abdominal pain, jaundice, nausea and weight loss are non-specific, so imaging and biopsy carry the diagnosis; MEN1 and Neurofibromatosis Type-1 are named as risks.
CD99 Positive Neoplastic Cells: Testing in Cancer
Cells carrying the CD99 protein appear in FLT3-ITDmut AML and in neuroblastoma; tumor genetic testing clarifies the diagnosis and points toward targeted therapy.
Decoding the Complexities of Cerebral Palsy Spastic Quadriplegic: Genetic Testing and Beyond
Discover the role of genetic testing in diagnosing cerebral palsy spastic quadriplegic, guiding personalized treatment plans, and informing prognosis for better outcomes.
Childhood Ganglioglioma: Seizures and Genetic Testing
Slow-growing tumors of nerve cells and supporting tissue, gangliogliomas in children cause seizures, headaches and neurological deficits.
Decoding the Mysteries of Choroidal Dystrophy: A Guide to Understanding, Diagnosing, and Genetic Testing
Discover the role of genetic testing in understanding and diagnosing Choroidal Dystrophy, a rare eye disorder. Learn about its causes, symptoms, and management strategies.