MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
An enlarged head and enlarged brain ventricles accompany the VATER/VACTERL pattern of anomalies, identified through examination, imaging and prenatal testing.
About 1 in 2,500 people of European descent lack the Vel antigen through an SMIM1 deletion; DNA typing of donors helps prevent reactions and assess HDFN risk.
Ultrasound, venography and D-dimer tests identify clots, while F11 duplication, PAI-1 polymorphisms and neutrophil activity are studied as genetic contributors.
A quantitative trait locus tied to blood vitamin B12 levels, VB12QTL1 relates to fatigue, numbness and memory problems, though diet and lifestyle also matter.
White blood cell count quantitative trait locus 1 shapes baseline WBC levels, platelet count and mean platelet volume; variant testing can inform blood disorder care.
Epidermolysis bullosa, Hailey-Hailey disease and Kindler syndrome each trace to a different gene: laminin 5, ATP2C1 and FERMT1 respectively.
Disrupted gyri and sulci in the cerebral cortex can bring developmental delay and cognitive problems, with MRI showing the folding pattern in detail.
Sugar molecules attached to amino acids keep proteins stable and cells signalling; when that attachment fails, thrombosis and immune escape can follow.