Decoding Low Alkaline Phosphatase: Understanding, Diagnosing, and Genetic Testing
When a blood test shows low ALP, the cause may be an ALPL gene mutation or hypophosphatasia, a rare disorder of bone mineralization tied to osteopenia.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Decoding the Mystery of Low-Set, Posteriorly Rotated Ears: Understanding, Diagnosing, and Genetic Testing
Discover the role of genetic testing in diagnosing disorders linked to low-set, posteriorly rotated ears, and learn how it aids in treatment, management, and family planning.
Unlocking the Mystery of Luteinizing Hormone Resistance in Females: A Comprehensive Guide
LHCGR gene mutations stop the LH receptor responding; in females this can cause infertility and irregular cycles, and genetic testing confirms the diagnosis.
Decoding Macrocephaly and Epileptic Encephalopathy: A Guide to Understanding, Diagnosis, and Genetic Testing
Seizures and cognitive impairment alongside an enlarged head call for MRI, clinical review and genetic testing, which can separate encephalopathy types.
Unlocking the Mysteries of Waldenstrom's Macroglobulinemia: Genetic Testing and Beyond
Discover the role of genetic testing in diagnosing Waldenstrom's Macroglobulinemia, a rare B-cell malignancy, and its impact on treatment and prognosis.
Decoding the Genetic Mysteries of Cerebral Malaria Susceptibility
Infected red blood cells massing in brain vessels cause this severe form of malaria; a TNF promoter polymorphism and genes found in Angolan children raise risk.
Unlocking the Secrets of Malignant Melanoma Susceptibility
Inherited mutations raise the odds of this skin cancer, and testing supports risk stratification, dermoscopy surveillance and sun-safety steps.
Demystifying Medium Chain Dicarboxylic Aciduria: A Comprehensive Guide to Understanding, Diagnosing, and Utilizing Genetic Testing
Deficiency of the peroxisomal enzyme EHHADH lets medium-chain dicarboxylic acids build up, causing liver damage and developmental delay; urine tests come first.