MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Discover the role of genetic testing in diagnosing short stature & advanced bone age caused by ACAN mutations, enabling targeted treatment and improved outcomes.
Variants in ACAN, the gene for aggrecan, can cause short stature with accelerated bone maturation and early-onset osteoarthritis; exome sequencing can detect them.
Ringed sideroblasts loaded with iron mark late-onset sideroblastic anemia; an ALAS2 splicing variant explains X-linked cases, some responsive to pyridoxine.
Sperm development halts before maturity, often producing azoospermia; semen analysis, testicular biopsy and AZF microdeletion testing are used to work out the cause.
Discover the rare genetic disorder Symphalangism affecting the 4th finger, its diagnosis methods, and how genetic testing can help in personalized treatment & family planning.
Some people break thiopurines down poorly and face stronger side effects; the page links genetic markers such as CYP2C19 to dosing choices and alternative therapies.
A quantitative trait locus is a stretch of DNA shaping a measurable trait, here TBG levels. SERPINA6/SERPINA1 variation is linked to cortisol and heart disease.
A non-healing tibia fracture or false joint often points to neurofibromatosis type 1. NF1 exome sequencing can confirm the cause and shape monitoring and counseling.