Hereditary Factor XIII Deficiency Disease: F13A1, F13B
Two faulty copies of F13A1 or F13B leave factor XIII missing or inactive, so clots are unstable, bleeding after injury is prolonged and wounds heal slowly.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Hereditary Nonpolyposis Colon Cancer: Understanding the Role of Genetic Testing
Faulty DNA mismatch repair genes raise the risk of colorectal and endometrial cancer without the usual polyps, so Lynch syndrome calls for earlier, regular screening.
Hereditary Retinoblastoma: Unlocking the Potential of Genetic Testing
About 40% of retinoblastoma cases come from RB1 mutations; testing identifies at-risk relatives, and prenatal diagnosis and newborn eye exams support early treatment.
Hereditary Sensory and Autonomic Neuropathy Type 1: SPTLC2
Symptoms begin in adolescence or early adulthood with numb limbs, muscle weakness and autonomic problems; a SPTLC2 mutation raises toxic 1-deoxysphingolipids in HSAN1.
Homozygous Familial Hypercholesterolemia: HoFH Genes
Very high LDL cholesterol from birth points to HoFH. The page covers LDL receptor, APOB and PCSK9 testing, family screening and how results shape treatment.
Hoyeraal-Hreidarsson Syndrome: Harnessing Genetic Testing for Better Understanding and Management
Explore how genetic testing enhances Hoyeraal-Hreidarsson syndrome diagnosis, treatment planning, and family counseling, offering hope for affected families.
Harnessing Genetic Insights in HTRA1-related Cerebral Small Vessel Disease
Mutations in the HTRA1 gene affect small blood vessels in the brain and give subtle symptoms; MRI findings plus DNA analysis support diagnosis and family screening.
Harnessing Genetic Insights: Understanding Hyper-IgE Syndrome
Elevated IgE with recurrent skin and lung infections marks this immunodeficiency; STAT3 findings and reduced chemoattractant receptor expression are both discussed.