Elevated Creatine Kinase: What High CK Levels Mean
Creatine kinase leaks into the blood when muscle tissue is damaged, so clinical review, laboratory tests, imaging and DMD gene analysis help trace the source.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Understanding, Diagnosing, and Using Genetic Testing for Epithelial Basement Membrane Dystrophy
Blurred vision and recurrent corneal erosions come from an irregular epithelial basement membrane; slit-lamp, fluorescein staining and topography reveal it.
Understanding, Diagnosing, and Using Genetic Testing for Epithelial Recurrent Erosion Dystrophy
Painful, repeating breakdown of the corneal epithelium defines ERED; TGFBI testing separates it from other corneal dystrophies and hints at how it will progress.
Understanding, Diagnosing, and Using Genetic Testing for Familial Cold Autoinflammatory Syndrome 1
Episodes of fever, rash and joint swelling begin in infancy in FCAS1; clinical criteria, CRP and ESR blood tests and NLRP3 sequencing all feed into the diagnosis.
Understanding, Diagnosing, and Using Genetic Testing for Febrile Seizures, Familial, 1
Fever-triggered convulsions usually begin between 6 months and 3 years and often stop by age 5; SCN1A analysis separates this autosomal dominant form from others.
Understanding, Diagnosing, and Using Genetic Testing for Fibrous Dysplasia of Jaw
Normal jaw bone gives way to fibrous tissue, causing facial asymmetry, pain and trouble chewing; GNAS mutations, ground-glass imaging and biopsy are covered.
Fleck Corneal Dystrophy: Slit-Lamp Signs and PIP5K3
Small white flecks in the corneal stroma often cause no symptoms; a slit-lamp exam and topography find them, and PIP5K3 testing can confirm fleck corneal dystrophy.
Understanding Gordon Syndrome: Diagnosis and Genetic Testing
Hand and foot contractures, short stature and facial differences mark Gordon syndrome, or distal arthrogryposis type 3; PIEZO2 analysis confirms it.