Atrial Fibrillation, Familial, 12: A Genetic Glimpse into the Heart's Rhythm
Frameshift deletion of MYL4 disturbs the atrial muscle fibers behind AFF12, an early-onset inherited arrhythmia; testing supports diagnosis, treatment and counseling.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Atrial Fibrillation, Familial, 9: Unveiling the Genetic Code Behind the Heart's Rhythm
Relatives who develop irregular heartbeats unusually young may share a frameshift deletion in MYL4, which testing can pinpoint to guide treatment and screening.
Advancements in Atrial Septal Defect 3: The Role of Genetic Testing
Often passed on in an autosomal dominant pattern, ASD3 leaves an opening in the atrial septum; genetic results support earlier diagnosis and family risk assessment.
Autoimmune Enteropathy and Endocrinopathy: Navigating the Genetic Pathways to Combat Chronic Infections
Immune attacks on the intestines and endocrine glands leave people prone to persistent infections. Genetic markers can confirm AEE-SCIS when symptoms overlap.
ADNSHL 64: Progressive Hearing Loss and Gene Tests
Progressive hearing impairment affecting only the auditory system defines ADNSHL 64. With over 100 hearing genes known, testing narrows which one is involved.
Auditory Anomalies: Understanding Autosomal Recessive Nonsyndromic Hearing Loss 29
Isolated hearing impairment with no syndromic features is what ARNSHL29 produces, and mutations in PKHD1L1 disrupt the hair-cell structures responsible for it.
How SCAR11 Affects Gait, Hands, Speech and Vision
Progressive incoordination of gait sits alongside hand, speech and eye movement problems in SCAR11. Testing confirms it and clarifies risk for relatives.
ARSCA12 Genotype and Phenotype: What Testing Shows
Matching a specific mutation to the symptoms it produces helps predict how ARSCA12 progresses; carrier testing and counseling build on that same result.