Prostate Cancer, Hereditary, 2: Genetic Testing's Role in Risk Assessment and Management
Inherited mutations raise prostate cancer risk within families, and identifying them supports earlier screening, treatment choices and testing for relatives.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Probing Pseudohypoaldosteronism Type 2B: The Role of Genetic Testing
Genetic testing aids in diagnosing Pseudohypoaldosteronism Type 2B, enabling personalized treatment plans and management of this rare genetic disorder effectively.
Probing the Pathways: Genetic Testing in Pseudohypoaldosteronism Type 2C
Hypertension, hyperkalemia and metabolic acidosis follow disturbed handling of sodium and potassium in the kidney; DNA analysis pinpoints the variants behind PHA2C.
PHA2C: Impaired Renal Salt Handling and Gene Testing
Raised blood pressure with high potassium points to impaired renal salt handling, and naming the causative variant separates PHA2C from overlapping kidney disorders.
Pseudohypoaldosteronism Type 2D: Diagnosis and Treatment
Impaired kidney handling of sodium and potassium drives hypertension and hyperkalemia; a confirmed gene variant sets PHA2D apart from essential hypertension.
Pseudohypoaldosteronism Type 2E and Aldosterone Response
An abnormal response to aldosterone leaves potassium high, blood pressure raised and the blood acidic; sequencing genes tied to PHA2E separates it from similar disorders.
Pioneering Pathways: Genetic Testing for Psychomotor Retardation, Epilepsy, and Craniofacial Dysmorphism
Developmental delays, recurrent seizures and distinct facial features define PRECD, which testing can confirm prenatally or soon after birth to guide care.
Unraveling the Mysteries of PYCR1-related De Barsy Syndrome Through Genetic Testing
Progeroid features, intellectual disability and skin abnormalities follow PYCR1 mutations, which whole exome trio sequencing identified in one Pakistani family.