MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Explore the role of genetic testing in diagnosing Pontocerebellar Hypoplasia Type 1B, enhancing precision in care, and uncovering complex genetic interactions.
Cavities in the cerebral hemispheres bring developmental delay, motor dysfunction and seizures in Porencephaly 2, where COL4A1 mutations have been implicated.
Ring-shaped, atrophic patches edged by a cornoid lamella characterize porokeratosis 7, where mutations in genes such as SLC17A9 affect skin cell growth.
High blood pressure with organ damage in pregnancy can progress to seizures, and an inherited tendency to hypertension raises that risk and shapes prenatal care.
Polymorphisms in APOH and NCF1 alter immune function and raise the risk of losing two or more pregnancies in women with antiphospholipid syndrome.
After two or more consecutive losses, testing may look at ADIPOQ, the gene for adiponectin, a hormone involved in metabolism and inflammation regulation.
A study in a Chinese population tied certain IL-17 genotypes and alleles to higher risk of repeated loss, which supports personalized risk assessment.
Symptoms of PCD17 overlap with commoner lung conditions, so finding a DNAH5 mutation can settle the diagnosis and shape treatment and counseling for relatives.