Genetic Insights: Decoding Peripheral Precocious Puberty
Early sexual development bypasses the hypothalamic-pituitary-gonadal axis and can stem from tumors, adrenal disorders or GNAS mutations in McCune-Albright syndrome.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Pinpointing Porphyria Cutanea Tarda: A Genetic Testing Guide
Photosensitivity, fragile skin and blistering follow a shortage of uroporphyrinogen decarboxylase, and UROD testing shows whether PCT is hereditary or acquired.
Primary Adrenocortical Insufficiency: Causes and Testing
Too little cortisol, and sometimes aldosterone, brings fatigue, weight loss and adrenal crises in Addison's disease; genetic causes such as CYP21A2 are examined.
Primary Peritoneal Carcinoma: BRCA1/BRCA2 and Diagnosis
Vague symptoms such as abdominal pain and bloating often delay diagnosis of PPC; BRCA1 and BRCA2 testing can flag inherited risk and point to targeted treatment.
Progressive Familial Intrahepatic Cholestasis: Unraveling the Genetic Mysteries
Impaired bile flow damages the liver from infancy, with jaundice, itching and poor weight gain; DNA testing separates PFIC1, PFIC2 and PFIC3 and guides care.
Pinpointing the Perils of Pulmonary Arterial Hypertension: The Role of Genetic Testing
High pressure in the lung arteries causes breathlessness, fatigue, chest pain and swollen ankles, and BMPR2 is the gene most often implicated in heritable cases.
Understanding Qualitative or Quantitative Defects of Alpha-Sarcoglycan
SGCA mutations weaken the sarcoglycan complex that holds muscle cell membranes together, causing limb-girdle weakness around the hips and shoulders.
Understanding the Role of Genetic Testing in Managing MYH7-Related Cardiomyopathies
Hypertrophic and dilated cardiomyopathy can both trace to the beta-myosin heavy chain gene, and MYH7 results inform surveillance, drug choice and reproductive options.