Analyzing Acute Liver Failure: The Genetic Testing Frontier
Whole-exome sequencing found a genetic cause in 37% of children studied with acute liver failure, with mitochondrial disease prominent; results can guide targeted care.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Advancing Understanding: Genetic Testing in Acute Megakaryoblastic Leukemia
Megakaryoblasts, the precursors to platelets, proliferate in AMKL; next-generation sequencing and FISH refine the diagnosis, stratify risk and track residual disease.
Acute Myeloid Leukemia: Unraveling the Genetic Threads of a Complex Disease
AML is not one disease but many, each with its own mutations; the GFI1-36N variant raises oxidative stress and DNA damage, and testing informs risk and treatment.
Advancements in Understanding Acute Myeloid Leukemia with Multilineage Dysplasia
Myelodysplasia-related and RUNX1 mutations mark a poorer outlook in AML with multilineage dysplasia, and exome sequencing can reclassify intermediate-risk cases.
Alpha-N-acetylgalactosaminidase Deficiency Type 3: Understanding Genetic Testing's Role
Symptoms of this lysosomal storage disease vary widely and mimic other conditions, so DNA testing is what confirms alpha-N-acetylgalactosaminidase deficiency type 3.
Alport Syndrome: Advances in Genetic Testing and Diagnosis
COL4A3, COL4A4 and COL4A5 mutations disturb the type IV collagen of the glomerular basement membrane, inner ear and eye in Alport syndrome.
Amelogenesis Imperfecta: Unraveling the Genetic Threads of Tooth Enamel Disorders
Explore how genetic testing enhances the diagnosis and management of amelogenesis imperfecta, a hereditary enamel disorder, ensuring personalized dental care.
Amyloidosis: Unraveling the Genetic Threads of a Complex Disease
Abnormal amyloid proteins settle in tissues and organs; sorting AL from ATTR and AA matters because a TTR mutation marks hereditary disease and changes treatment.