Acquired Long QT Syndrome 5: Genetics and ECG Imaging
Common genetic variation shapes LQTS susceptibility, while electrocardiographic imaging maps repolarization; genetic testing identifies relatives at risk.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Decoding the Enigma of Acquired Long QT Syndrome 6: Genetic Testing Unlocks the Mystery
Medications, electrolyte imbalance or another illness can lengthen the QT interval, and common variation explains an estimated 15% of LQTS susceptibility.
LDL Cholesterol Level Quantitative Trait Locus 1 Genes
A FADS1 polymorphism links miR-1908-5p to lower circulating LDL-C through TGFB1 and BMP1, while common and rare PCSK9 variants also shift cholesterol levels.
LDL-C QTL6: Causal Genes, Diet and Family Risk
Mendelian randomization using MR-link pointed to 19 genes causally tied to LDL-C, among them SORT1 and PVRL2; dietary changes and family risk are also covered.
Decoding Male Germ Cell Tumors: Genetic Testing and Somatic-Type Malignancies
Molecular studies of these testicular tumors show widespread aneuploidy, distinct epigenetic signatures and rare mutations; testing guides treatment choices.
Cracking the Code: Understanding and Diagnosing MERRF/MELAS Overlap Syndrome through Genetic Testing
Myoclonus and seizures from MERRF can appear with stroke-like episodes and lactic acidosis from MELAS, and sequencing mitochondrial DNA pins down the mutation.
Decoding the Genetic Mysteries of Migraines: A Comprehensive Guide
Research on familial risk points to a strong genetic component in migraine, with depression often co-occurring; MYORG findings and medication overuse also feature.
Decoding the Genetic Puzzle of Mild Short Stature: Understanding, Diagnosing, and Using Genetic Testing
Height well below average for age and sex can trace to SHOX deficiency, ACAN, IGF1 haploinsufficiency or an NDUFB3 mutation, each found through DNA analysis.