MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Underdevelopment of the pancreas can surface as neonatal diabetes or exocrine insufficiency; ultrasound, MRI, blood work and gene analysis each contribute to a diagnosis.
Tremor, rigidity, bradykinesia and postural instability define this group of disorders, assessed with clinical exams, MRI or PET imaging and genetic testing.
Palpitations, breathlessness and fatigue can signal PAF, an intermittent irregular heartbeat found on ECG, with genetic risk scores used to assess susceptibility.
Underdevelopment of the brain's largest white matter connection can bring cognitive, motor and social difficulties; MRI and genetic testing clarify the cause.
Extra fingers or toes, often fused together, define polysyndactyly. Examination and X-rays establish the diagnosis, and DNA analysis can support prenatal screening.
Involuntary shaking while holding a position, postural tremor can accompany Parkinson's disease, essential tremor or multiple sclerosis, so exams help sort the causes.
No periods by age 16 can trace back to Turner syndrome or to mutations in INHA and PCSK1; karyotyping and targeted gene tests, with their limits, are described.
Blocked drainage channels raise intraocular pressure and can damage the optic nerve; variants including TGFB2 rs991967 have been linked to higher POAG risk.