Increased Circulating IgE Levels: Genes and Triggers
A transcriptome-wide association study tied 59 genes to circulating IgE, while parasitic infections such as trichinosis and soil exposure also affect levels.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Decoding the Mystery of Intervertebral Disk Calcification: Understanding, Diagnosing, and Genetic Testing
Calcium salts deposited in the discs of the cervical spine cause pain in children; CT and MRI confirm PIIDC, and animal studies point to possible genetic factors.
Decoding Intraventricular Hemorrhage: Understanding, Diagnosing, and Genetic Testing
Premature babies are the group most affected when blood leaks into the brain's ventricles; ultrasound, CT or MRI confirms it, and family studies point to genetic risk.
Unlocking the Secrets of Iron Overload: A Comprehensive Guide
Too much stored iron can damage the liver, heart and pancreas; ferritin and transferrin saturation tests, HFE variants and phlebotomy are each described.
Understanding Juvenile Hemochromatosis: A Genetic Approach to Diagnosis and Treatment
Iron builds up early in life, risking cardiomyopathy, diabetes and hormone problems; HJV gene testing with liver iron measurement can confirm the diagnosis.
Decoding Leukoencephalopathy: Understanding, Diagnosing, and Genetic Testing
NOTCH3 mutations in CADASIL and CSF1R mutations in a second form show why MRI alone rarely settles the diagnosis of these progressive white matter disorders.
Decoding Leydig Cell Hypoplasia Type 1: Understanding, Diagnosing, and Utilizing Genetic Testing
Absent testosterone production can leave a 46,XY child with female external genitalia; hormone levels and LHCGR sequencing establish the diagnosis.
Decoding Lingual Thyroid: Understanding, Diagnosing, and Genetic Testing
Thyroid tissue at the base of the tongue can affect breathing, swallowing and speech. Diagnosis uses imaging, thyroid function tests and molecular testing.