Bilateral Cleft Lip: Causes, Repair and Gene Testing
Two clefts either side of the upper lip form when facial structures do not fuse in the womb. Diagnosis, surgical repair, obturators and alveolar grafting are covered.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Unraveling the Mystery of Bilateral Cryptorchidism: Genetic Testing and Diagnosis
When neither testicle descends, infertility and testicular neoplasia can follow. HOXA11 and GREAT gene findings are linked to diagnosis, surgery and hormone therapy.
Decoding Bilateral Sensorineural Hearing Impairment: Genetic Testing Unravels the Mystery
Damage to the inner ear or auditory nerve in both ears can trace back to SLC26A4, GJB2 or DFNB59. Audiometry, BAER testing and gene testing are explained here.
Deciphering the Genetic Code: Understanding and Diagnosing Genetic Blindness
Inherited eye disorders such as optic nerve hypoplasia and CEP290-linked Leber congenital amaurosis are outlined, alongside negative ERGs and pupillometry.
Brachydactyly Syndrome Type E: PDE3A and HDAC4 Variants
Underdeveloped or missing bones shorten the fingers and toes in BDE, which has been traced to PDE3A and HDAC4 changes alongside hypertension or developmental delay.
Decoding the Genetic Mysteries of Pancreatic Cancer: Understanding, Diagnosing, and Using Genetic Testing
Studies of Kras, 15-PGDH and PDX1 signaling show how pancreatic tumors form, while testing identifies inherited risk, informs treatment choices and tracks response.
Decoding the Mystery of Digenic Midventricular Hypertrophic Cardiomyopathy: Understanding, Diagnosing, and Genetic Testing
Thickening in the middle of the left ventricle can obstruct blood flow and form apical aneurysms; cardiac MRI and whole-exome sequencing can reveal digenic inheritance.
Unlocking the Mysteries of Cerebral Atrophy: Genetic Testing and Beyond
Loss of brain cells has many causes, and reported cases link it to NLRP3, EXOSC3 and TREX1 variants, which can point toward treatments aimed at the underlying disorder.