MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Mutations in the APOB gene lower apolipoprotein B and LDL cholesterol, letting fat build up in the liver and leading to vitamin deficiencies and neurological problems.
A blood or saliva sample analyzed by PCR and DNA sequencing can reveal HbF-QTL5 variants; higher HbF levels are linked to a milder sickle cell disease course.
Inflammation, gallstones and cancer risk are tied to gallbladder disease 4, and DNA analysis is described as a route to earlier diagnosis and targeted treatment.
The TNF-308*AA genotype has been tied to primary open-angle glaucoma while TCF4 rs613872 has not; cost, unknown variants and emotional impact temper testing.
Trabecular meshwork that fails to develop raises pressure in PCG; SVEP1 modifies TEK-related disease, and CYP1B1 mutations affect surgical outcome and prognosis.
Inherited forms most often trace to MC2R, MRAP or NNT mutations; testing supports early diagnosis, prenatal counseling and long-term management.
Blood tests, imaging and AGL gene analysis together point to GSD IIIa, a debranching enzyme disorder linked to muscle weakness, growth delay and liver enlargement.
Discover the importance of genetic testing in diagnosing and managing Glycogen Storage Disease IIIb, its symptoms, and how it impacts liver function and overall health.