Obesity Resistance: GRASP55, PEPD and LTB4 Research
Some people stay lean on a high-fat diet. Studies of Grasp55 in mice, macrophage PEPD in adipose tissue and LTB4/Ltb4r1 signaling are summarized, with testing uses.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Unraveling the Mystery of Oculoskeletodental Syndrome: A Guide to Genetic Testing
Eye, skeletal and dental features of oculoskeletodental syndrome include cataracts, scoliosis and enamel hypoplasia; genetic testing helps confirm a diagnosis.
Deciphering the Mysteries of Optic Nerve Dysplasia: Genetic Testing and Beyond
Nystagmus, strabismus and reduced visual acuity can follow underdevelopment of the optic nerve, alone or within McCune Albright or renal coloboma syndrome.
Decoding Palmoplantar Hyperkeratosis and True Hermaphroditism: A Comprehensive Guide to Genetic Testing
Skin thickening on the palms and soles can occur with both male and female reproductive tissue present; RSPO1 mutations link the two, and testing supports counseling.
Somatic Parathyroid Adenoma: MEN1, CASR and Tumor Testing
Somatic mutations arise in parathyroid cells rather than the germline, so they are not passed on; MEN1, CASR, EZH2 and FAT1 are among the genes found in these tumors.
Decoding Periventricular Laminar Heterotopia: Embracing Genetic Testing for Better Understanding and Diagnosis
Neurons that stop short in fetal development form nodules beside the lateral ventricles, linked to epilepsy and developmental delay; array-CGH is a first-line test.
Unraveling the Mosaic: Understanding Polyostotic Fibrous Dysplasia
Fibrous tissue replaces normal bone in PFD, bringing pain, deformity and fractures, and the somatic mutations behind it arise during development and are not inherited.
PPARGC1B Polymorphism: Energy Metabolism and Health Risks
Variation in the PPARGC1B gene, which helps regulate cellular energy metabolism, has been linked with autism spectrum disorder, short stature and pregnancy loss.