Unlocking the Mystery of Insulin Resistance Susceptibility: A Comprehensive Guide
Studies in Hungarian and Roma populations, plus Jazf1 work in mice, point to inherited factors behind insulin resistance and show where genetic testing can flag risk.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Decoding the Mystery of Intractable Seizures: Genetic Testing Unravels the Unknown
Seizures that resist antiepileptic drugs affect about 30% of people with epilepsy; a stepwise genetic workup can name a cause and point toward targeted therapy.
Decoding the Mysteries of AIPL1-Related Juvenile Retinitis Pigmentosa
Mutations in the AIPL1 gene damage photoreceptors, causing the early vision loss of juvenile retinitis pigmentosa; eye exams, ERG, OCT and DNA analysis identify it.
Karak Syndrome: Seizures and Developmental Delay
A rare neurodevelopmental disorder, Karak syndrome brings developmental delays, intellectual disability and seizures that overlap with other conditions.
Late-Onset Citrullinemia: Urea Cycle and Testing
Ammonia builds up when the urea cycle falters, causing recurrent fever, arthritis and skin rashes that appear later in life than in other forms.
Early-Onset Leprosy: Genetic Susceptibility Factors
Genes tied to immune response and inflammation may shape who develops leprosy early; the page weighs what testing could add for diagnosis.
Leprosy: TLR1 and TLR2 Variants in Susceptibility
Hansen's disease affects skin, peripheral nerves and the airway lining, and TLR1 and TLR2 polymorphisms are the genetic link described here.
Leukemia After Chemotherapy: EVI1 and ME1 Markers
After chemotherapy some patients relapse or develop secondary malignant neoplasms; EVI1 disruption and ME1 expression are discussed as markers that guide monitoring.