MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Iron builds up in the liver, pancreas and brain when the ceruloplasmin gene is mutated; low serum ceruloplasmin, high ferritin and MRI findings support the diagnosis.
Antiviral pressure, rapid replication and an error-prone polymerase let resistant HBV strains emerge; pol gene sequencing detects the mutations and the viral genotype.
Inflammation and LDL cholesterol are described as two separate causal pathways for atherosclerotic disease, and this locus is examined alongside them by QTL analysis.
Low 21-hydroxylase activity leaves cortisol short and androgens high, bringing hirsutism, acne and irregular periods. CYP21A2 analysis confirms it and finds carriers.
Genes as well as diet and exercise shape cholesterol levels; zebrafish ldlr work and cardiovascular linkage studies underpin risk assessment and cascade screening.
Nearly half of people with hypertension see blood pressure climb with salt. Salt-sensitive hypertension, its genetic markers and renal injury are covered.
Low sex hormones and delayed puberty occur here without loss of smell, which makes HH5 harder to spot. Hormone tests, imaging and gene findings are set out.
A severe combined immunodeficiency variant linked to NHEJ1 and RAG1 variants, where TRECs and KRECs measurement aids detection and stem cell transplantation is used.