MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Recurrent fever, abdominal pain, diarrhea and failure to thrive follow severe gut inflammation; targeted NLRC4 testing or whole exome sequencing can confirm SCAN4.
Head circumference well below average for age can signal a wider genetic syndrome; cytogenetic and gene testing help find causes such as Angelman syndrome or RUSC2.
Hormone receptor-positive breast cancer is often treated with tamoxifen, yet response varies; genetic and transcriptomic markers may predict benefit and side effects.
Missing or faulty factor VIII slows clot formation, causing bruising, joint pain and prolonged bleeding; the X-linked pattern makes males more often affected.
Some people gain little pain relief from tramadol while others meet side effects. Variants affecting drug metabolism, transport and targets help explain the difference.
Not everyone reacts to tretinoin the same way. Polymorphisms in the RAR and RXR genes, plus skin barrier and inflammation genes, may influence treatment response.
The enzyme helps build serotonin, which regulates mood, appetite and sleep, while related YWHAZ research covers lung and ovarian cancer resistance.
Both conditions trace back to TSC1 or TSC2 faults that leave the mTOR pathway overactive. Lung cysts, benign tumors, mTOR inhibitors and prenatal testing feature.