Juvenile-Onset Psychosis: Diagnosis and Genetic Risk
Hallucinations, delusions and disorganized thinking in children and teens call for careful differential diagnosis; testing may inform medication choices.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Unlocking the Mysteries of KCNT2-Related Conditions: A Comprehensive Guide
Seizures, developmental delays and intellectual disability characterize these rare KCNT2 disorders, where the variant found guides treatment and prognosis.
Unlocking the Mysteries of Adult-Onset Leukodystrophy: Genetic Testing for Diagnosis and Treatment
Case reports covering MTHFR deficiency, Alexander disease with GFAP mutations, LMNB1 duplication and an AARS2 mutation show how DNA analysis pins down the subtype.
Lipoatrophy, Diabetes and Cardiomyopathy: R133L in LMNA
A single R133L change in LMNA has been reported alongside generalized lipoatrophy, insulin-resistant diabetes, fatty liver, thickened heart muscle and skin papules.
Nijmegen Breakage Syndrome: NBN Gene and Lung Damage
Mutations in NBN impair nibrin and DNA repair, causing microcephaly, immunodeficiency and recurrent respiratory infections; diagnosis and carrier testing are explained.
Non-Obstructive Azoospermia: Genes Behind Male Infertility
Many cases of azoospermia have no obvious cause, so sequencing looks for variants such as an MSH4 stop-gain mutation or DDX3Y changes in the AZFa region.
Cracking the Code of Male Infertility: Understanding Spermatogenesis Disorder
Y chromosome microdeletions in AZF genes, Nphp1 and a mir-34 b/c polymorphism are linked to faulty sperm production, and PGD or carrier screening can follow.
Decoding the Enigma: Understanding Malignant Hyperthermia Equivocal with Halothane
When the in vitro contracture test with halothane and caffeine returns an equivocal result, 4-CmC and RYR1 gene analysis can sharpen the diagnosis.