Piroxicam Response and CYP2C9: Pharmacogenetic Testing
CYP2C9 variants change how quickly the body breaks down piroxicam, an NSAID used for arthritis and menstrual pain, affecting drug levels, dosing and side-effect risk.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Understanding, Diagnosing, and Using Genetic Testing for Combined and Isolated Pituitary Hormone Deficiency
When the pituitary cannot make one or more hormones, growth failure and delayed puberty can result; PROP1, POU1F1, HESX1 and LHX3 are among the genes analyzed.
PARP Inhibitor Response: BRCA1, BRCA2 and Other Genes
Blocking the PARP enzyme leaves cancer cells less able to repair DNA damage, and BRCA1, BRCA2, ATM, CHEK2 and PALB2 variants help predict who responds to these drugs.
How Genetics Affects Pravastatin Response and LDL Levels
Pravastatin blocks HMG-CoA reductase to lower LDL cholesterol, but responses vary, and genetic differences in metabolism can be tested to guide treatment choices.
Unlocking the Mystery of Premature Ovarian Failure 21: Genetic Testing and Beyond
Irregular periods, hot flashes and low estrogen can point to Premature Ovarian Failure 21; hormone blood work, pelvic ultrasound and DNA analysis are outlined.
Unlocking the Mystery of Programmed Death Ligand-1 (PD-L1) Blocking Antibody Response
Discover the importance of understanding and diagnosing PD-L1 blocking antibody response in cancer treatment, and how genetic testing can optimize therapy outcomes.
Understanding, Diagnosing, and Using Genetic Testing for Progressive Childhood Encephalopathy
Cognitive, motor and sensory decline in children is worked up with MRI or CT, EEG and metabolic and genetic tests that can name the mutation behind the disorder.
Prostate Cancer Susceptibility: How Genetic Testing Works
Blood or saliva can be analyzed for known risk mutations alongside PSA testing and rectal exams, though results cannot say how aggressive a prostate cancer will be.