MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Genetic insights into partial congenital absence of teeth (hypodontia) help diagnosis, treatment plans, and family counseling for missing teeth, improving oral health outcomes.
Premature fusion of skull bones shapes the head and face in Pfeiffer syndrome, along with hand and foot differences; DNA analysis looks for FGFR1 or FGFR2 changes.
Primary and secondary polycythemia differ in cause. The JAK2 V617F mutation appears in about 95% of Polycythemia Vera cases and can confirm that diagnosis.
Loss of ovarian function before 40 brings irregular periods, hot flashes and infertility; FSH, estradiol and karyotype testing plus FMR1 findings are set out here.
MRI, biopsy and histopathology identify these small, round, blue cell tumors; finding the EWSR1-FLI1 fusion gene confirms PNET and can shape treatment choices.
Weak abdominal muscles, undescended testicles and urinary tract abnormalities form the triad of Eagle-Barrett syndrome; imaging and CHRM3 findings support the workup.
External genitalia that do not match chromosomal or gonadal sex define the male and female forms; karyotyping, hormone levels and imaging precede genetic testing.
Explore Pseudohypoparathyroidism Type I A (PHP1A), its symptoms, diagnosis, and the pivotal role of genetic testing in personalized treatment and family planning.