MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Squamous cell carcinoma is the most common type, arising in the mouth, throat and salivary glands; exams, imaging and biopsy confirm it, and tumor testing adds prognosis.
Benign vascular tumors appear soon after birth in about 5-10% of babies, grow quickly, then fade; diagnosis is mostly clinical, with imaging or biopsy when unclear.
Hemolytic disease of the fetus or newborn (HDFN) due to isoimmunization is a serious condition that occurs when the mother's immune system produces antibodies…
Cancer cells carrying extra HER2 protein are identified by IHC scoring and FISH; BRCA1 and BRCA2 testing informs risk, and trastuzumab and pertuzumab target HER2.
Amyloid deposits in cerebral blood vessels raise the risk of intracerebral hemorrhage; CST3 testing confirms HCAA-I, and maternal inheritance is linked to earlier onset.
Weakened brain vessel walls rupture repeatedly, bringing strokes and cognitive decline; MRI, CT and APP gene testing confirm HCHWA, an autosomal dominant disorder.
Growing on the outer surface of bone, this cancer can mimic other tumors on imaging, so biopsy confirms it; TP53 and RB1 have been linked to osteosarcoma.
Molar pregnancy brings vaginal bleeding, rapid uterine growth and raised hCG. Ultrasound, hCG levels and QF-PCR chromosome analysis separate complete from partial moles.