MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Premature fusion of cranial sutures from TWIST1 mutations can occur alone or as Saethre-Chotzen syndrome. Clinical signs, CT imaging and surgical planning are described.
Autoimmune destruction of pancreatic beta cells drives T1DM2, with HLA region genes raising risk. Blood glucose, HbA1c and autoantibody tests are explained.
Hearing loss in one ear, also called single-sided deafness, is assessed by audiometry and imaging; GJB2 and SLC26A4 testing can explain an unclear cause.
Eye, facial and cognitive development are all affected in this rare disorder, diagnosed by physical exam, imaging and genetic testing that guides surgical planning.
Cleft lip, cleft palate and pits on the lower lip follow autosomal dominant IRF6 mutations, confirmed by single-gene tests, panels or whole exome sequencing.
Variants in CYP2C9 and VKORC1 change how fast warfarin is metabolized and how sensitive a patient is, so testing can inform starting dose and risk stratification.
Irregular cycles, infertility and pelvic pain can point to the ovaries; cysts, tumors, Turner and Fragile X syndrome are covered with BRCA1 and BRCA2 testing.
Dark, velvety patches on the neck, armpits and groin are often tied to insulin resistance; examination, blood tests, skin biopsy and related syndromes are described.