MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Autosomal recessive inheritance means both parents carry the altered gene; VCKD can bring developmental delays, motor difficulty, kidney dysfunction and hypertension.
CYP27B1 mutations block conversion of 25-hydroxyvitamin D into calcitriol, so calcium and phosphate absorption falls and bone pain, bowed legs and delayed growth follow.
An autosomal dominant change in the VCAN gene drives the vitreoretinal degeneration and progressive vision loss of Wagner syndrome, which testing can confirm.
Explore how genetic testing transforms Worth disease management, offering personalized treatment, early diagnosis, and insights for family planning and research.
Caused by CUL7, OBSL1 or CCDC8 mutations and inherited recessively, 3-M syndrome brings severe growth retardation, a triangular face and short long bones.
Amyloid plaques build up in the brain when BRI2 (ITM2B) is mutated, causing the dementia, ataxia and neuropathy of ADan amyloidosis; MRI and PET support diagnosis.
Passed on in an autosomal dominant pattern, ALS4 is confirmed by SETX gene testing after EMG, nerve conduction studies and MRI rule out other disorders.
Liver disease, pulmonary artery stenosis, butterfly vertebrae and posterior embryotoxon point to this autosomal dominant disorder caused by JAG1 or NOTCH2.