MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Variants in TLR4 and TLR7 raise osteoarthritis risk while a miR-196a2 variant appears protective, and testing can flag who might act early on weight and joint care.
Also called retinitis pigmentosa, this inherited group degrades photoreceptors and affects night and peripheral vision; over 80 genes have been implicated.
A firm lump under the skin arising from hair follicle matrix cells is benign but can mimic other lesions; CTNNB1 mutations affecting beta-catenin underlie its formation.
Faulty type VII collagen from COL7A1 mutations leaves shin skin fragile and quick to blister; PDEB diagnosis, family planning and clinical trials are explained.
Episodes of burning pain, warmth and redness in the hands and feet can overlap with Fabry disease; testing for variants such as GLA helps separate the two.
Mutations in the erythropoietin (EPO) receptor drive overproduction of red blood cells; testing confirms the diagnosis, screens relatives and guides treatment.
Soft tissue gradually turns to bone when ACVR1 mutations misdirect bone morphogenetic protein signaling, starting with painful flare-ups in early childhood.
High potassium, metabolic acidosis and hypertension can start in infancy, as in a 2-month-old who went into hypovolemic shock; gene testing confirms PHA2A early.