Mastocytosis: Unraveling the Genetic Threads of a Complex Disease
Mast cells build up in skin, bone marrow and other organs, causing skin lesions, bone pain and sometimes anaphylaxis; the KIT D816V mutation marks the systemic form.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Mapping Medulloblastoma: The Role of Genetic Testing in Unraveling Brain Cancer Mysteries
Arising in the cerebellum and mainly affecting children, medulloblastoma is profiled by tumor sequencing, with EP300 and CBP studied in the Group 3 subtype.
Melanoma and Neural System Tumor Syndrome: CDKN2A
Inherited changes in CDKN2A are linked to multiple melanomas and nervous system tumors in MNSTS, a hereditary syndrome that often runs in families.
Melanoma, Cutaneous Malignant: Navigating the Genetic Roadmap to Susceptibility
Variants in CDKN2A, BAP1 and MC1R can raise inherited melanoma risk, prompting closer skin examinations, sun protection and more informed treatment choices.
What MCMS2 Means for Melanoma Risk and Screening
MCMS2 involves gene changes affecting cell growth and repair that leave skin less able to cope with UV damage; blood or saliva panels can detect them.
Melorheostosis: Understanding the Genetic Blueprint of a Rare Bone Disorder
Explore the genetic insights into melorheostosis, a rare bone disorder. Learn how genetic testing aids in diagnosis and personalized treatment strategies.
Meniere Disease: Decoding the Mysteries of the Inner Ear
Recurrent vertigo, fluctuating hearing loss and tinnitus define this inner ear disorder, where genetic markers, biomarkers and imaging may sharpen diagnosis.
Metachondromatosis: Unlocking the Mysteries of a Rare Bone Disorder through Genetic Testing
Benign enchondromas and osteochondromas can distort bone growth in this rare inherited disorder, which stems from PTPN11 mutations that gene testing identifies.